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dc.contributor.authorFrizziero, Melissa
dc.contributor.authorWang, Xin
dc.contributor.authorChakrabarty, Bipasha
dc.contributor.authorChilds, A
dc.contributor.authorLuong, TV
dc.contributor.authorWalter, T
dc.contributor.authorKhan, MS
dc.contributor.authorMorgan, M
dc.contributor.authorChristian, A
dc.contributor.authorElshafie, M
dc.contributor.authorShah, T
dc.contributor.authorMinicozzi, Annamaria
dc.contributor.authorMansoor, Was
dc.contributor.authorMeyer, T
dc.contributor.authorLamarca, Angela
dc.contributor.authorHubner, Richard A
dc.contributor.authorValle, Juan W
dc.contributor.authorMcNamara, Mairead G
dc.date.accessioned2019-12-09T17:23:39Z
dc.date.available2019-12-09T17:23:39Z
dc.date.issued2019en
dc.identifier.citationFrizziero M, Wang X, Chakrabarty B, Childs A, Luong TV, Walter T, et al. Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres. World J Gastroenterol. 2019;25(39):5991-6005.en
dc.identifier.pmid31660035en
dc.identifier.doi10.3748/wjg.v25.i39.5991en
dc.identifier.urihttp://hdl.handle.net/10541/622628
dc.description.abstractAIM: To investigate clinical-pathological characteristics, treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN. METHODS: Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres. Patient data were retrospectively collected from medical records. Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN. Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1. Kaplan-Meier analysis was applied to estimate survival outcomes. Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions (univariate) and Cox-regression analysis (multivariable). RESULTS: Sixty-nine consecutive patients identified; Median age at diagnosis: 64 years. Males: 63.8%. Localised disease (curable): 53.6%. Commonest sites of origin: colon-rectum (43.5%) and oesophagus/oesophagogastric junction (15.9%). The neuroendocrine component was; predominant in 58.6%, poorly differentiated in 86.3%, and large cell in 81.25%, of cases analysed. Most distant metastases analysed (73.4%) were occupied only by a poorly differentiated neuroendocrine component. Ninety-four percent of patients with localised disease underwent curative surgery; 53% also received perioperative treatment, most often in line with protocols for adenocarcinomas from the same sites of origin. Chemotherapy was offered to most patients (68.1%) with advanced disease, and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion. In localised cases, median recurrence free survival (RFS); 14.0 mo (95%CI: 9.2-24.4), and median overall survival (OS): 28.6 mo (95%CI: 18.3-41.1). On univariate analysis, receipt of perioperative treatment (vs surgery alone) did not improve RFS (P = 0.375), or OS (P = 0.240). In advanced cases, median progression free survival (PFS); 5.6 mo (95%CI: 4.4-7.4), and median OS; 9.0 mo (95%CI: 5.2-13.4). On univariate analysis, receipt of palliative active treatment (vs best supportive care) prolonged PFS and OS (both, P < 0.001). CONCLUSION: MiNEN is most commonly driven by a poorly differentiated neuroendocrine component, and has poor prognosis. Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.3748/wjg.v25.i39.5991en
dc.titleRetrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centresen
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX,en
dc.identifier.journalWorld Journal of Gastroenterologyen
refterms.dateFOA2020-02-01T13:57:06Z


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