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dc.contributor.authorHiggins, KA
dc.contributor.authorGorgens, S
dc.contributor.authorSudmeier, LJ
dc.contributor.authorFaivre-Finn, Corinne
dc.date.accessioned2019-12-09T17:23:39Z
dc.date.available2019-12-09T17:23:39Z
dc.date.issued2019en
dc.identifier.citationHiggins KA, Gorgens S, Sudmeier LJ, Faivre-Finn C. Recent developments in limited stage small cell lung cancer. Transl Lung Cancer Res. 2019;8(Suppl 2):S147-S52.en
dc.identifier.pmid31673519en
dc.identifier.doi10.21037/tlcr.2019.05.13en
dc.identifier.urihttp://hdl.handle.net/10541/622624
dc.description.abstractLimited stage small cell lung cancer (LS-SCLC) remains a challenging disease, with 5-year overall survival ranging from 30-35% with current standard of care treatment consisting of thoracic radiation to 45 Gy in 30 fractions delivered twice daily, with concurrent platinum/etoposide chemotherapy, followed by prophylactic cranial irradiation (PCI). The randomized, phase III CONVERT study confirmed 45 Gy delivered twice daily to be the optimal radiation fractionation regimen, without significantly increased toxicity when compared to daily radiation to 66 Gy. Immunotherapy is now being studied in addition to chemoradiation, in both the concurrent and consolidative setting. These randomized trials are ongoing. Additionally, the role of PCI compared to MRI surveillance is being evaluated in patients with LS-SCLC in both the North America and Europe. Ideally these ongoing studies will continue to improve outcomes for LS-SCLC.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.21037/tlcr.2019.05.13en
dc.titleRecent developments in limited stage small cell lung canceren
dc.typeArticleen
dc.contributor.departmentDepartment of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USAen
dc.identifier.journalTranslational Lung Cancer Researchen
refterms.dateFOA2020-02-01T13:53:20Z


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