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dc.contributor.authorGorgoulis, Vassilis G
dc.contributor.authorAdams, PD
dc.contributor.authorAlimonti, A
dc.contributor.authorBennett, DC
dc.contributor.authorBischof, O
dc.contributor.authorBishop, C
dc.contributor.authorCampisi, J
dc.contributor.authorCollado, M
dc.contributor.authorEvangelou, K
dc.contributor.authorFerbeyre, G
dc.contributor.authorGil, J
dc.contributor.authorHara, E
dc.contributor.authorKrizhanovsky, V
dc.contributor.authorJurk, D
dc.contributor.authorMaier, AB
dc.contributor.authorNarita, M
dc.contributor.authorNiedernhofer, L
dc.contributor.authorPassos, JF
dc.contributor.authorRobbins, PD
dc.contributor.authorSchmitt, CA
dc.contributor.authorSedivy, J
dc.contributor.authorVougas, K
dc.contributor.authorZhou, D
dc.contributor.authorSerrano, M
dc.contributor.authorDemaria, M
dc.contributor.authorvon Zglinicki, T
dc.date.accessioned2019-12-09T17:08:21Z
dc.date.available2019-12-09T17:08:21Z
dc.date.issued2019en
dc.identifier.citationGorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, et al. Cellular Senescence: Defining a Path Forward. Cell. 2019;179(4):813-27.en
dc.identifier.pmid31675495en
dc.identifier.doi10.1016/j.cell.2019.10.005en
dc.identifier.urihttp://hdl.handle.net/10541/622574
dc.description.abstractCellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.cell.2019.10.005en
dc.titleCellular senescence: defining a path forwarden
dc.typeArticleen
dc.contributor.departmentMolecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greeceen
dc.identifier.journalCellen
dc.description.noteen


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