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    Cellular senescence: defining a path forward

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    Authors
    Gorgoulis, Vassilis G
    Adams, PD
    Alimonti, A
    Bennett, DC
    Bischof, O
    Bishop, C
    Campisi, J
    Collado, M
    Evangelou, K
    Ferbeyre, G
    Gil, J
    Hara, E
    Krizhanovsky, V
    Jurk, D
    Maier, AB
    Narita, M
    Niedernhofer, L
    Passos, JF
    Robbins, PD
    Schmitt, CA
    Sedivy, J
    Vougas, K
    Zhou, D
    Serrano, M
    Demaria, M
    von Zglinicki, T
    Show allShow less
    Affiliation
    Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.
    Citation
    Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, et al. Cellular Senescence: Defining a Path Forward. Cell. 2019;179(4):813-27.
    Journal
    Cell
    URI
    http://hdl.handle.net/10541/622574
    DOI
    10.1016/j.cell.2019.10.005
    PubMed ID
    31675495
    Additional Links
    https://dx.doi.org/10.1016/j.cell.2019.10.005
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cell.2019.10.005
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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