Authors
Gorgoulis, Vassilis GAdams, PD
Alimonti, A
Bennett, DC
Bischof, O
Bishop, C
Campisi, J
Collado, M
Evangelou, K
Ferbeyre, G
Gil, J
Hara, E
Krizhanovsky, V
Jurk, D
Maier, AB
Narita, M
Niedernhofer, L
Passos, JF
Robbins, PD
Schmitt, CA
Sedivy, J
Vougas, K
Zhou, D
Serrano, M
Demaria, M
von Zglinicki, T
Affiliation
Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, GreeceIssue Date
2019
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Show full item recordAbstract
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.Citation
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, et al. Cellular Senescence: Defining a Path Forward. Cell. 2019;179(4):813-27.Journal
CellDOI
10.1016/j.cell.2019.10.005PubMed ID
31675495Additional Links
https://dx.doi.org/10.1016/j.cell.2019.10.005Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1016/j.cell.2019.10.005
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