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    Minimal clinically important difference of the EORTC QLQ-CIPN20 for worsening peripheral neuropathy in patients receiving neurotoxic chemotherapy.

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    Authors
    Yeo, F
    Ng, CC
    Loh, KWJ
    Molassiotis, A
    Cheng, HL
    Au, JSK
    Leung, KT
    Li, YC
    Wong, K-H
    Suen, L
    Chan, CW
    Yorke, Janelle
    Farrell, Carole
    Bandla, A
    Ang, E,
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    Affiliation
    Department of Pharmacy, National University of Singapore, Blk S4A Level 3, 18 Science Drive 4, Singapore, 117543, Singapore
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    CONTEXT/OBJECTIVES: This is the first study to determine the minimal clinically important difference (MCID) of the European Organisation of Research and Treatment of Cancer Quality of Life Questionnaire-CIPN twenty-item scale (EORTC QLQ-CIPN20), a validated instrument designed to elicit cancer patients' experience of symptoms and functional limitations related to chemotherapy-induced peripheral neuropathy. METHODS: Cancer patients receiving neurotoxic chemotherapy completed EORTC QLQ-CIPN20 and the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity [FACT/GOG-NTX] at baseline, second cycle of chemotherapy (T2, n?=?287), and 12 months after chemotherapy (T3, n?=?191). Anchor-based approach used the validated FACT/GOG-NTX neurotoxicity (Ntx) subscale to identify optimal MCID cutoff for deterioration. Distribution-based approach used one-third standard deviation (SD), half SD, and one standard error of measurement of the total EORTC QLQ-CIPN20 score. RESULTS: There was a moderate correlation between the change scores of the Ntx subscale and sensory and motor subscales of QLQ-CIPN20 (T2: r?=?-?0.722, p?<?0.001 and r?=?-?0.518, p?<?0.001, respectively; T3: r?=?-?0.699; p?<?0.001 and r?=?-?0.523, p?<?0.001, respectively). The correlation between the change scores of the Ntx subscale and the QLQ-CIPN20 autonomic subscale was poor (T2: r?=?-?0.354, p?<?0.001; T3: r?=?0.286, p?<?0.001). Based on the MCID derived using distribution-based method, the MCID for the QLQ-CIPN20 sensory subscale was 2.5-5.9 (6.9% to 16.4% of the subdomain score) and for motor subscale was 2.6-5.0 (8.1%-15.6% of the subdomain score). CONCLUSION: The MCID for the EORTC QLQ-CIPN20 established using distribution-based approaches was 2.5-5.9 for the sensory subscale and 2.6-5.0 for the motor subscale. When noted in assessments even with small change in scores, clinicians can be alerted for appropriate intervention.
    Citation
    Yeo F, Ng CC, Loh KWJ, Molassiotis A, Cheng HL, Au JSK, et al. Minimal clinically important difference of the EORTC QLQ-CIPN20 for worsening peripheral neuropathy in patients receiving neurotoxic chemotherapy. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 2019;27(12):4753-62.
    Journal
    Supportive Care in Cancer
    URI
    http://hdl.handle.net/10541/622568
    DOI
    10.1007/s00520-019-04771-8
    PubMed ID
    30972646
    Additional Links
    https://dx.doi.org/ 10.1007/s00520-019-04771-8
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00520-019-04771-8
    Scopus Count
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