Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013-2015
Valle, Juan W
AffiliationNeuroendocrine Tumour Patients Foundation, Leamington Spa, UK
MetadataShow full item record
AbstractBACKGROUND: The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. METHODS: Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates (SMRs) were calculated for all malignant NENs diagnosed 2013-2015 from UK national Public Health records. Comparison with non-NENs assessed 1-year overall survival (1YS) and association between diagnosis at stage IV and morphology. RESULTS: A total of 15,222 NENs were identified, with an ASR (2013-2015 combined) of 8.6 per 100,000 (95% CI 8.5-8.7); 4.6 per 100 000 (95% CI, 4.5-4.7) for gastro-entero-pancreatic (GEP) NENs. The 1YS was 75% (95% CI, 73.9-75.4) varying significantly by sex. Site and morphology were prognostic. NENs (predominantly small cell carcinomas) in the oesophagus, bladder, prostate, and female reproductive organs had a poorer outcome and were three times more likely to be diagnosed at stage IV than non-NENs. CONCLUSION: Advanced stage at diagnosis with significantly poorer outcomes of some NENs compared with non-NENs at the same anatomical site, highlight the need for improved access to specialist services and targeted service improvement.
CitationGenus TSE, Bouvier C, Wong KF, Srirajaskanthan R, Rous BA, Talbot DC, et al. Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013-2015. Br J Cancer. 2019;121(11):966-72.
JournalBritish Journal of Cancer
- Stage IV Gastro-Entero-Pancreatic Neuroendocrine Neoplasms: A Risk Score to Predict Clinical Outcome.
- Authors: Panzuto F, Merola E, Pavel ME, Rinke A, Kump P, Partelli S, Rinzivillo M, Rodriguez-Laval V, Pape UF, Lipp R, Gress T, Wiedenmann B, Falconi M, Delle Fave G
- Issue date: 2017 Apr
- Recent epidemiology of patients with gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NEN) in Japan: a population-based study.
- Authors: Masui T, Ito T, Komoto I, Uemoto S, JNETS Project Study Group.
- Issue date: 2020 Nov 14
- Incidence trends of lung and gastroenteropancreatic neuroendocrine neoplasms in Switzerland.
- Authors: Alwan H, La Rosa S, Andreas Kopp P, Germann S, Maspoli-Conconi M, Sempoux C, Bulliard JL
- Issue date: 2020 Dec
- Variability of the Ki-67 proliferation index in gastroenteropancreatic neuroendocrine neoplasms - a single-center retrospective study.
- Authors: Shi H, Zhang Q, Han C, Zhen D, Lin R
- Issue date: 2018 Jul 28
- Clinicopathological features and prognosis of gastroenteropancreatic neuroendocrine neoplasms in a Chinese population: a large, retrospective single-centre study.
- Authors: Zhang M, Zhao P, Shi X, Zhao A, Zhang L, Zhou L
- Issue date: 2017 Jul 13