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    Identifying skeletal-related events for prostate cancer patients in routinely collected hospital data

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    Authors
    Parry, MG
    Cowling, TE
    Sujenthiran, A
    Nossiter, J
    Berry, B
    Cathcart, P
    Clarke, Noel W
    Payne, H
    Aggarwal, A
    van der Meulen, J
    Affiliation
    Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, United Kingdom;
    Issue Date
    2019
    
    Metadata
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    Abstract
    BACKGROUND: Non-osteoporotic skeletal-related events (SREs) are clinically important markers of disease progression in prostate cancer. We developed and validated an approach to identify SREs in men with prostate cancer using routinely-collected data. METHODS: Patients diagnosed with prostate cancer between January 2010 and December 2013 were identified in the National Prostate Cancer Audit, based on English cancer registry data. A coding framework was developed based on diagnostic and procedure codes in linked national administrative hospital and routinely-collected radiotherapy data to identify SREs occurring before December 2015. Two coding definitions of SREs were assessed based on whether the SRE codes were paired with a bone metastasis code ('specific definition') or used in isolation ('sensitive definition'). We explored the validity of both definitions by comparing the cumulative incidence of SREs from time of diagnosis according to prostate cancer stage at diagnosis with death as a competing risk. RESULTS: We identified 40,063, 25,234 and 13,968 patients diagnosed with localised, locally advanced and metastatic disease, respectively. Using the specific definition, we found that the 5-year cumulative incidence of SREs was 1.0 % in patients with localised disease, 6.0 % in patients with locally advanced disease, and 42.3 % in patients with metastatic disease. Using the sensitive definition, the corresponding cumulative incidence figures were 9.0 %, 14.9 %, and 44.4 %, respectively. CONCLUSION: The comparison of the cumulative incidence of SREs identified in routinely collected hospital data, based on a specific coding definition in patients diagnosed with different prostate cancer stage, supports their validity as a clinically important marker of cancer progression.
    Citation
    Parry MG, Cowling TE, Sujenthiran A, Nossiter J, Berry B, Cathcart P, et al. Identifying skeletal-related events for prostate cancer patients in routinely collected hospital data. Cancer Epidemiol. 2019;63:101628.
    Journal
    Cancer Epidemiology
    URI
    http://hdl.handle.net/10541/622555
    DOI
    10.1016/j.canep.2019.101628
    PubMed ID
    31715436
    Additional Links
    https://dx.doi.org/10.1016/j.canep.2019.101628
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.canep.2019.101628
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