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    Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of the European Society of Radiology (ESR)

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    Authors
    de Souza, NM
    Achten, E
    Alberich-Bayarri, A
    Bamberg, F
    Boellaard, R
    Clement, O
    Fournier, L
    Gallagher, F
    Golay, X
    Heussel, CP
    Jackson, EF
    Manniesing, R
    Mayerhofer, ME
    Neri, E
    O'Connor, James P B
    Oguz, KK
    Persson, A
    Smits, M
    van Beek, EJR
    Zech, CJ
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    Affiliation
    Cancer Research UK Imaging Centre, The Institute of Cancer Research and The Royal Marsden Hospital, Downs Road, Sutton, Surrey
    Issue Date
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    Abstract
    Observer-driven pattern recognition is the standard for interpretation of medical images. To achieve global parity in interpretation, semi-quantitative scoring systems have been developed based on observer assessments; these are widely used in scoring coronary artery disease, the arthritides and neurological conditions and for indicating the likelihood of malignancy. However, in an era of machine learning and artificial intelligence, it is increasingly desirable that we extract quantitative biomarkers from medical images that inform on disease detection, characterisation, monitoring and assessment of response to treatment. Quantitation has the potential to provide objective decision-support tools in the management pathway of patients. Despite this, the quantitative potential of imaging remains under-exploited because of variability of the measurement, lack of harmonised systems for data acquisition and analysis, and crucially, a paucity of evidence on how such quantitation potentially affects clinical decision-making and patient outcome. This article reviews the current evidence for the use of semi-quantitative and quantitative biomarkers in clinical settings at various stages of the disease pathway including diagnosis, staging and prognosis, as well as predicting and detecting treatment response. It critically appraises current practice and sets out recommendations for using imaging objectively to drive patient management decisions.
    Citation
    deSouza NM, Achten E, Alberich-Bayarri A, Bamberg F, Boellaard R, Clement O, et al. Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of the European Society of Radiology (ESR). Insights Imaging. 2019 Aug 29;10(1):87.
    Journal
    Insights in Imaging
    URI
    http://hdl.handle.net/10541/622220
    DOI
    10.1186/s13244-019-0764-0
    PubMed ID
    31468205
    Additional Links
    https://dx.doi.org/10.1186/s13244-019-0764-0
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13244-019-0764-0
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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