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    Emerging epigenetic therapeutic targets in acute myeloid leukemia

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    Authors
    Wingelhofer, Bettina
    Somervaille, Tim CP
    Affiliation
    Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, University of Manchester, Manchester
    Issue Date
    2019
    
    Metadata
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    Abstract
    Acute myeloid leukemia (AML) is a genetically heterogeneous malignancy for which treatment options have been largely limited to cytotoxic chemotherapy for the past four decades. Next-generation sequencing and other approaches have identified a spectrum of genomic and epigenomic alterations that contribute to AML initiation and maintenance. The key role of epigenetic modifiers and the reversibility of epigenetic changes have paved the way for evaluation of a new set of drug targets, and facilitated the design of novel candidate treatment strategies. More recently, seven new targeted therapies have been FDA-approved demonstrating successful implementation of the past decades' research. In this review, we will summarize the most recent advances in targeted therapeutics designed for a focused group of key epigenetic regulators in AML, outline their mechanism of action and their current status in clinical development. Furthermore, we will discuss promising new approaches for epigenetic targeted treatment in AML which are currently being tested in pre-clinical trials.
    Citation
    Wingelhofer B, Somervaille TCP. Emerging epigenetic therapeutic targets in acute myeloid leukemia. Front Oncol. 2019;9:850.
    Journal
    Frontiers in Oncology
    URI
    http://hdl.handle.net/10541/622216
    DOI
    10.3389/fonc.2019.00850
    PubMed ID
    31552175
    Additional Links
    https://dx.doi.org/10.3389/fonc.2019.00850
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3389/fonc.2019.00850
    Scopus Count
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    All Paterson Institute for Cancer Research

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