Name:
dev148296.full.pdf
Size:
1.370Mb
Format:
PDF
Description:
Full text, Open Access article
Affiliation
Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Alderley Edge, Macclesfield SK10 4TG,Issue Date
2019
Metadata
Show full item recordAbstract
RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.Citation
Mevel R, Draper JE, Lie ALM, Kouskoff V, Lacaud G. RUNX transcription factors: orchestrators of development. Development. 2019 Sep 5;146(17).Journal
DevelopmentDOI
10.1242/dev.148296PubMed ID
31488508Additional Links
https://dx.doi.org/10.1242/dev.148296Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1242/dev.148296
Scopus Count
Collections
Related articles
- RUNX3 in Stem Cell and Cancer Biology.
- Authors: Chuang LSH, Matsuo J, Douchi D, Bte Mawan NA, Ito Y
- Issue date: 2023 Jan 25
- Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulation.
- Authors: Bae SC, Lee YH
- Issue date: 2006 Jan 17
- The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease.
- Authors: Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, Takeda S
- Issue date: 2008 Sep
- RUNX factors in development: lessons from invertebrate model systems.
- Authors: Braun T, Woollard A
- Issue date: 2009 Jul-Aug
- Role of Runx proteins in chondrogenesis.
- Authors: Yoshida CA, Komori T
- Issue date: 2005