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    RUNX transcription factors: orchestrators of development

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    Authors
    Mevel, R
    Draper, JE
    Lie-A-Ling, Michael
    Kouskoff, Valerie
    Lacaud, Georges
    Affiliation
    Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Alderley Edge, Macclesfield SK10 4TG,
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.
    Citation
    Mevel R, Draper JE, Lie ALM, Kouskoff V, Lacaud G. RUNX transcription factors: orchestrators of development. Development. 2019 Sep 5;146(17).
    Journal
    Development
    URI
    http://hdl.handle.net/10541/622214
    DOI
    10.1242/dev.148296
    PubMed ID
    31488508
    Additional Links
    https://dx.doi.org/10.1242/dev.148296
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1242/dev.148296
    Scopus Count
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    All Paterson Institute for Cancer Research

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