AffiliationCancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Alderley Edge, Macclesfield SK10 4TG,
MetadataShow full item record
AbstractRUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.
CitationMevel R, Draper JE, Lie ALM, Kouskoff V, Lacaud G. RUNX transcription factors: orchestrators of development. Development. 2019 Sep 5;146(17).
- The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease.
- Authors: Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, Takeda S
- Issue date: 2008 Sep
- Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulation.
- Authors: Bae SC, Lee YH
- Issue date: 2006 Jan 17
- RUNX factors in development: lessons from invertebrate model systems.
- Authors: Braun T, Woollard A
- Issue date: 2009 Jul-Aug
- Role of Runx proteins in chondrogenesis.
- Authors: Yoshida CA, Komori T
- Issue date: 2005
- Characterization of the Runx gene family in a jawless vertebrate, the Japanese lamprey (Lethenteron japonicum).
- Authors: Nah GS, Tay BH, Brenner S, Osato M, Venkatesh B
- Issue date: 2014