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dc.contributor.authorPrior, TS
dc.contributor.authorHoyer, N
dc.contributor.authorShaker, SB
dc.contributor.authorDavidsen, JR
dc.contributor.authorYorke, Janelle
dc.contributor.authorHilberg, O
dc.contributor.authorBendstrup, E
dc.date.accessioned2019-10-07T15:16:41Z
dc.date.available2019-10-07T15:16:41Z
dc.date.issued2019en
dc.identifier.citationPrior TS, Hoyer N, Shaker SB, Davidsen JR, Yorke J, Hilberg O, et al. Validation of the IPF-specific version of St. George's Respiratory Questionnaire. Respir Res. 2019 Aug 28;20(1):199.en
dc.identifier.pmid31462235en
dc.identifier.doi10.1186/s12931-019-1169-9en
dc.identifier.urihttp://hdl.handle.net/10541/622194
dc.description.abstractBACKGROUND: Patients with idiopathic pulmonary fibrosis (IPF) have impaired health-related quality of life (HRQL). To measure HRQL, an IPF-specific version of the St. George's Respiratory Questionnaire (SGRQ-I) was developed, but not sufficiently validated. This study aimed to assess the validity (i.a. known-groups validity and concurrent validity) and test-retest reliability of SGRQ-I in IPF patients with different disease durations. METHODS: Patients with IPF were consecutively recruited and completed SGRQ, SGRQ-I, King's Brief Interstitial Lung Disease questionnaire (K-BILD), University of California, San Diego Shortness of Breath Questionnaire (SOBQ) and Short Form-36 (SF-36) along with pulmonary function tests and a 6-min walk test (6MWT) at baseline. After two weeks, SGRQ-I and Global Rating of Change Scales (GRCS) were completed. RESULTS: At baseline and after two weeks, 150 and 134 patients completed the questionnaires, respectively. The internal consistency of SGRQ-I was high (Cronbach's ??=?0.92). Good concurrent validity was demonstrated by high intraclass correlation coefficients (ICC?=?0.97), Bland-Altman plots and moderate to strong correlations to K-BILD, SOBQ and SF-36 (r?=?-?0.46 to 0.80). High ICC (0.92) and a Bland-Altman plot indicated good test-retest reliability. SGRQ-I was good at discriminating between patients with different stages of disease (?score >?18.1, effect sizes >?0.10). Validity was similar across groups of different disease duration. CONCLUSIONS: SGRQ-I proved to be valid at distinguishing between different disease severities, valid compared to other HRQL instruments, applicable across different disease durations and reliable upon repetition. SGRQ-I is a valid option for measuring HRQL in patients with IPF. TRIAL REGISTRATION: The study was registered at clinicaltrials.org ( NCT02818712 ) on 15 June 2016.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1186/s12931-019-1169-9en
dc.titleValidation of the IPF-specific version of St. George's Respiratory Questionnaireen
dc.typeArticleen
dc.contributor.departmentDepartment of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.en
dc.identifier.journalRespiratory Researchen
dc.description.noteen]
refterms.dateFOA2019-10-24T20:39:02Z


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