Duodenal neuroendocrine tumour associated with minimal change glomerulonephritis
Affiliation
Medical Oncology, Christie NHS Foundation Trust, Manchester, UKIssue Date
2019
Metadata
Show full item recordAbstract
Paraneoplastic glomerular disease is an increasingly well-recognised entity, and a wide range of both solid and haematological malignancies have been implicated. The most common glomerular disease associated with cancer is membranous nephropathy. Only a few case reports have described an association between neuroendocrine tumours (NETs) and glomerulonephritis and only one paediatric case in relation to minimal change disease. A 76-year-old woman with a well-differentiated duodenal NET presented with nephrotic syndrome and renal biopsy was suggestive of minimal change glomerulonephritis. Standard therapy with corticosteroids brought little benefit, but a dramatic improvement was seen following initiation of systemic anticancer therapy with lanreotide, a somatostatin analogue. Less than 1?month after initiation of lanreotide, the patient was no longer in a nephrotic state, and after a further 2 months of follow-up had shown no sign of relapse.Citation
Montague E, Hockenhull K, Lamarca A, Al-Sayed T, Hubner RA. Duodenal neuroendocrine tumour associated with minimal change glomerulonephritis. BMJ Case Rep. 2019 Aug 30;12(8).Journal
BMJ Case ReportsDOI
10.1136/bcr-2018-227987PubMed ID
31473631Additional Links
https://dx.doi.org/10.1136/bcr-2018-227987Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1136/bcr-2018-227987
Scopus Count
Collections
Related articles
- Minimal change glomerular disease: a paraneoplastic syndrome in two patients with bronchogenic carcinoma.
- Authors: Moorthy AV
- Issue date: 1983 Jul
- Minimal change nephrotic syndrome with cecum adenocarcinoma.
- Authors: Gandini E, Allaria P, Castiglioni A, d'Amato I, Schiaffino E, Giangrande A
- Issue date: 1996 Apr
- Minimal change nephropathy associated with anaplastic carcinoma of bronchus.
- Authors: Singer CR, Boulton-Jones JM
- Issue date: 1986 Mar
- Renal disease and syphilis: a report of nephrotic syndrome with minimal change disease.
- Authors: Krane NK, Espenan P, Walker PD, Bergman SM, Wallin JD
- Issue date: 1987 Feb
- [Secondary glomerulonephritis in neurofibromatosis type 1. Two case reports].
- Authors: Orera A, Lacarra S, Fernández L, Gómez N, Slon MF, Manrique J
- Issue date: 2019 Dec 5