Unusual skull base metastasis from neuroendocrine tumor: a case report
AffiliationDepartment of Medical Oncology, The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester, M20 4BX
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AbstractBACKGROUND: With increasing treatment options available, neuroendocrine tumor has become a chronic disease and may present later on with atypical manifestation of disease spread once resistant to treatment. CASE PRESENTATION: A 74-year-old white British woman undergoing treatment for metastatic well-differentiated neuroendocrine tumor for the past 9?years presented with a brief history of mild frontal headache, and progressive left ptosis and ocular palsy. She had no visual loss, and had neither speech nor motor deficit. At the outset, it was crucial to exclude acute or missed stroke. An urgent magnetic resonance imaging of her head revealed an unusual skull base metastasis extending into the cavernous sinus, with no peritumoral edema. Following discussion at a specialist neuro-oncology meeting and a neuroendocrine tumor multidisciplinary team meeting, she proceeded to have conventional fractionated radiotherapy followed by subsequent palliative chemotherapy. CONCLUSIONS: Intracranial metastasis is rare in patients with neuroendocrine tumor, particularly in those with well-differentiated histology; skull base metastasis is even more uncommon. Management of intracranial metastasis from a rare tumor should always be discussed in a specialist multidisciplinary meeting. Surgery or radiotherapy, including stereotactic radiosurgery, should be considered in skull base metastases. Hormonal abnormalities may occur following radiotherapy to skull base metastases and should be monitored closely in the first few months post treatment.
CitationLim KHJ, Valle JW, Lamarca A. Unusual skull base metastasis from neuroendocrine tumor: a case report. J Med Case Rep. 2019 Aug 30;13(1):273.
JournalJournal of Medical Case Reports
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- Authors: Kotecha R, Angelov L, Barnett GH, Reddy CA, Suh JH, Murphy ES, Neyman G, Chao ST
- Issue date: 2014 Dec
- Cavernous sinus syndrome as the first manifestation of metastatic breast disease.
- Authors: Seixas NB, Belsuzarri TAB, Belsuzarri NCB, Pozetti M, Araujo JFM
- Issue date: 2017
- Regarding: Rosenthal DI, Glatstein E. "We've Got a Treatment, but What's the Disease?" The Oncologist 1996;1.
- Authors: Lunsford LD, Flickinger JC, Larson D
- Issue date: 1997
- Metastatic Liposarcoma of the Skull Base: A Case Report and Review of Literature.
- Authors: Zagzoog N, Ra G, Koziarz A, Provias J, Sommer D, Almenawer SA, Reddy K
- Issue date: 2017 Apr 1