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    EORTC SPECTA-AYA: a unique molecular profiling platform for adolescents and young adults with cancer in Europe

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    Rojas_et_al-2019-International ...
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    Authors
    de Rojas, T
    Kasper, B
    Van der Graaf, W
    Pfister, SM
    Bielle, F
    Ribalta, T
    Shenjere, Patrick
    Preusser, M
    Frohling, S
    Golfinopoulos, V
    Morfouace, M
    McCabe, Martin
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    Affiliation
    EORTC Headquarters, Brussels, BelgiumSarcoma Unit, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany
    Issue Date
    2019
    
    Metadata
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    Abstract
    For most adolescent and young adult (AYA) cancers, age-specific molecular features are poorly understood. EORTC-SPECTA, an academic translational research infrastructure for biomaterial collection, will explicitly recruit AYA patients and will therefore collect empirical data to bridge the molecular gap between pediatric and adult oncology. The initial pilot study, activated in February 2019 across Europe, will recruit 100 AYA patients (aged 12-29?years) with newly diagnosed or relapsed high-grade gliomas and high-grade bone and soft tissue sarcomas. The primary objective of the pilot is to determine feasibility and recruitment rates. Formalin-fixed tumor tissue and whole blood from study participants will be prospectively collected with clinical data and stored centrally at the Integrated BioBank of Luxembourg. Whole exome sequencing of matched tumor and blood, and tumor RNA sequencing and DNA methylation profiling will be performed at the German Cancer Research Center, Heidelberg, Germany. Virtual central pathology review of scanned diagnostic slides will be undertaken by an international expert panel, and diagnostic material returned to the participating centers. A multidisciplinary molecular tumor board will release a clinically validated report to referring clinicians within 4-6?weeks after biopsy. SPECTA-AYA constitutes a major opportunity to gain knowledge about the tumor biology of this unique age group. It incorporates notable innovative aspects: AYA specificity, pan-European academic collaboration, centralized biobanking, comprehensive molecular profiling and virtual central pathology review, among others. SPECTA-AYA will help untangle the tumor particularities of AYAs with cancer and aims to improve their access to novel drugs and personalized medicine.
    Citation
    de Rojas T, Kasper B, Van der Graaf W, Pfister SM, Bielle F, Ribalta T, et al. EORTC SPECTA-AYA: a unique molecular profiling platform for adolescents and young adults with cancer in Europe. Int J Cancer. 2019 Aug 29.
    Journal
    International Journal of Cancer
    URI
    http://hdl.handle.net/10541/622167
    DOI
    10.1002/ijc.32651
    PubMed ID
    31465545
    Additional Links
    https://dx.doi.org/10.1002/ijc.32651
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.32651
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