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    Machine learning and data mining frameworks for predicting drug response in cancer: an overview and a novel in silico screening process based on association rule mining

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    Authors
    Vougas, K
    Sakellaropoulos, T
    Kotsinas, A
    Foukas, GP
    Ntargaras, A
    Koinis, F
    Polyzos, A
    Myrianthopoulos, V
    Zhou, H
    Narang, S
    Georgoulias, V
    Alexopoulos, L
    Aifantis, I
    Townsend, Paul A
    Sfikakis, P
    Fitzgerald, R
    Thanos, D
    Bartek, J
    Petty, R
    Tsirigos, A
    Gorgoulis, Vassilis G
    Show allShow less
    Affiliation
    Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Str., Athens GR-11527, Greece
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    A major challenge in cancer treatment is predicting the clinical response to anti-cancer drugs on a personalized basis. The success of such a task largely depends on the ability to develop computational resources that integrate big "omic" data into effective drug-response models. Machine learning is both an expanding and an evolving computational field that holds promise to cover such needs. Here we provide a focused overview of: 1) the various supervised and unsupervised algorithms used specifically in drug response prediction applications, 2) the strategies employed to develop these algorithms into applicable models, 3) data resources that are fed into these frameworks and 4) pitfalls and challenges to maximize model performance. In this context we also describe a novel in silico screening process, based on Association Rule Mining, for identifying genes as candidate drivers of drug response and compare it with relevant data mining frameworks, for which we generated a web application freely available at: https://compbio.nyumc.org/drugs/. This pipeline explores with high efficiency large sample-spaces, while is able to detect low frequency events and evaluate statistical significance even in the multidimensional space, presenting the results in the form of easily interpretable rules. We conclude with future prospects and challenges of applying machine learning based drug response prediction in precision medicine.
    Citation
    Vougas K, Sakellaropoulos T, Kotsinas A, Foukas GP, Ntargaras A, Koinis F, et al. Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining. Pharmacol Ther. 2019 Jul 30:107395.
    Journal
    Pharmacology and Therapeutics
    URI
    http://hdl.handle.net/10541/622158
    DOI
    10.1016/j.pharmthera.2019.107395
    PubMed ID
    31374225
    Additional Links
    https://dx.doi.org/10.1016/j.pharmthera.2019.107395
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.pharmthera.2019.107395
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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