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    How liquid biopsies can change clinical practice in oncology

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    Authors
    Siravegna, G
    Mussolin, B
    Venesio, T
    Marsoni, S
    Seoane, J
    Dive, Caroline
    Papadopoulos, N
    Kopetz, S
    Corcoran, RB
    Siu, LL
    Bardelli, A
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    Affiliation
    Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy
    Issue Date
    2019
    
    Metadata
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    Abstract
    Cell-free DNA fragments are shed into the bloodstream by tumor cells. The analysis of circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a variety of clinical applications. ctDNA is being used to genotype solid cancers non-invasively, to track tumor dynamics and to detect the emergence of drug resistance. In a few settings, liquid biopsies have already entered clinical practice. For example, ctDNA is used to guide treatment in a subset of lung cancers. In this review, we discuss how recent improvements in the sensitivity and accuracy of ctDNA analyses have led to unprecedented advances in this research field. We further consider what is required for the routine deployment of liquid biopsies in the clinical diagnostic space. We pinpoint technical hurdles that liquid biopsies have yet to overcome, including pre-analytical and analytical challenges. We foresee how liquid biopsies will transform clinical practice: by complementing (or replacing) imaging to monitor treatment response and by detecting minimal residual disease after surgery with curative intent.
    Citation
    Siravegna G, Mussolin B, Venesio T, Marsoni S, Seoane J, Dive C, et al. How liquid biopsies can change clinical practice in oncology. Ann Oncol. 2019 Aug 2.
    Journal
    Annals of Oncology
    URI
    http://hdl.handle.net/10541/622152
    DOI
    10.1093/annonc/mdz227
    PubMed ID
    31373349
    Additional Links
    https://dx.doi.org/10.1093/annonc/mdz227
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1093/annonc/mdz227
    Scopus Count
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    All Paterson Institute for Cancer Research

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