AffiliationCandiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy
MetadataShow full item record
AbstractCell-free DNA fragments are shed into the bloodstream by tumor cells. The analysis of circulating tumor DNA (ctDNA), commonly known as liquid biopsy, can be exploited for a variety of clinical applications. ctDNA is being used to genotype solid cancers non-invasively, to track tumor dynamics and to detect the emergence of drug resistance. In a few settings, liquid biopsies have already entered clinical practice. For example, ctDNA is used to guide treatment in a subset of lung cancers. In this review, we discuss how recent improvements in the sensitivity and accuracy of ctDNA analyses have led to unprecedented advances in this research field. We further consider what is required for the routine deployment of liquid biopsies in the clinical diagnostic space. We pinpoint technical hurdles that liquid biopsies have yet to overcome, including pre-analytical and analytical challenges. We foresee how liquid biopsies will transform clinical practice: by complementing (or replacing) imaging to monitor treatment response and by detecting minimal residual disease after surgery with curative intent.
CitationSiravegna G, Mussolin B, Venesio T, Marsoni S, Seoane J, Dive C, et al. How liquid biopsies can change clinical practice in oncology. Ann Oncol. 2019 Aug 2.
JournalAnnals of Oncology
- Nanotechnology Strategies for the Analysis of Circulating Tumor DNA: A Review.
- Authors: Chen X, Wang L, Lou J
- Issue date: 2020 Mar 22
- Liquid biopsy and its role in an advanced clinical trial for lung cancer.
- Authors: Johann DJ Jr, Steliga M, Shin IJ, Yoon D, Arnaoutakis K, Hutchins L, Liu M, Liem J, Walker K, Pereira A, Yang M, Jeffus SK, Peterson E, Xu J
- Issue date: 2018 Feb
- Liquid biopsy in non-small cell lung cancer: a key role in the future of personalized medicine?
- Authors: Pi C, Zhang MF, Peng XX, Zhang YC, Xu CR, Zhou Q
- Issue date: 2017 Dec
- Role of liquid biopsies in colorectal cancer.
- Authors: Wills B, Gorse E, Lee V
- Issue date: 2018 Nov
- Dynamic Treatment Stratification Using ctDNA.
- Authors: Vidal J, Taus A, Montagut C
- Issue date: 2020