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    Transcriptional control of blood cell emergence

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    Authors
    Menegatti, S
    de Kruijf, M
    Garcia-Alegria, E
    Lacaud, Georges
    Kouskoff, V
    Affiliation
    Developmental Haematopoiesis Group, Faculty of Biology, Medicine and Health, the University of Manchester, UK
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    The haematopoietic system is established during embryonic life through a series of developmental steps that culminates with the generation of haematopoietic stem cells. Characterisation of the transcriptional network that regulates blood cell emergence has led to the identification of transcription factors essential for this process. Among the many factors wired within this complex regulatory network, ETV2, SCL and RUNX1 are the central components. All three factors are absolutely required for blood cell generation, each one controlling a precise step of specification from the mesoderm germ layer to fully functional blood progenitors. Insight into the transcriptional control of blood cell emergence has been used for devising protocols to generate blood cells de novo, either through reprogramming of somatic cells or through forward programming of pluripotent stem cells. Interestingly, the physiological process of blood cell generation and its laboratory-engineered counterpart have very little in common.
    Citation
    Menegatti S, de Kruijf M, Garcia-Alegria E, Lacaud G, Kouskoff V. Transcriptional control of blood cell emergence. FEBS Lett. 2019 Aug 21.
    Journal
    FEBS Letters
    URI
    http://hdl.handle.net/10541/622149
    DOI
    10.1002/1873-3468.13585
    PubMed ID
    31432499
    Additional Links
    https://dx.doi.org/10.1002/1873-3468.13585
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1002/1873-3468.13585
    Scopus Count
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