Preclinical dosimetry: exploring the use of small animal phantoms
AffiliationDivision of Cancer Sciences, University of Manchester, Manchester Cancer Research Centre, 3rd floor Proton Beam Therapy Centre, Oak Road, Manchester, M20 4BX, UK
MetadataShow full item record
AbstractPreclinical radiotherapy studies using small animals are an indispensable step in the pathway from in vitro experiments to clinical implementation. As radiotherapy techniques advance in the clinic, it is important that preclinical models evolve to keep in line with these developments. The use of orthotopic tumour sites, the development of tissue-equivalent mice phantoms and the recent introduction of image-guided small animal radiation research platforms has enabled similar precision treatments to be delivered in the laboratory.These technological developments, however, are hindered by a lack of corresponding dosimetry standards and poor reporting of methodologies. Without robust and well documented preclinical radiotherapy quality assurance processes, it is not possible to ensure the accuracy and repeatability of dose measurements between laboratories. As a consequence current RT-based preclinical models are at risk of becoming irrelevant.In this review we explore current standardization initiatives, focusing in particular on recent developments in small animal irradiation equipment, 3D printing technology to create customisable tissue-equivalent dosimetry phantoms and combining these phantoms with commonly used detectors.
CitationBiglin ER, Price GJ, Chadwick AL, Aitkenhead AH, Williams KJ, Kirkby KJ. Preclinical dosimetry: exploring the use of small animal phantoms. Radiat Oncol. 2019 Jul 31;14(1):134.
- Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research.
- Authors: Soultanidis G, Subiel A, Renard I, Reinhart AM, Green VL, Oelfke U, Archibald SJ, Greenman J, Tulk A, Walker A, Schettino G, Cawthorne CJ
- Issue date: 2019 Jun 21
- Investigating the accuracy of microstereotactic-body-radiotherapy utilizing anatomically accurate 3D printed rodent-morphic dosimeters.
- Authors: Bache ST, Juang T, Belley MD, Koontz BF, Adamovics J, Yoshizumi TT, Kirsch DG, Oldham M
- Issue date: 2015 Feb
- Characterizing 3D printing in the fabrication of variable density phantoms for quality assurance of radiotherapy.
- Authors: Madamesila J, McGeachy P, Villarreal Barajas JE, Khan R
- Issue date: 2016 Jan
- A dosimetric study on the use of 3D-printed customized boluses in photon therapy: A hydrogel and silica gel study.
- Authors: Kong Y, Yan T, Sun Y, Qian J, Zhou G, Cai S, Tian Y
- Issue date: 2019 Jan
- Canine anatomic phantom for preclinical dosimetry in internal emitter therapy.
- Authors: Padilla L, Lee C, Milner R, Shahlaee A, Bolch WE
- Issue date: 2008 Mar