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    T-cell receptor and chimeric antigen receptor in solid cancers: current landscape, preclinical data and insight into future developments

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    Authors
    Azizi, Alexander
    Pillai, Manon
    Thistlethwaite, Fiona C
    Affiliation
    Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    PURPOSE OF REVIEW: The remarkable and durable clinical responses seen in certain solid tumours using checkpoint inhibitors and in haematological malignancies using chimeric antigen receptor (CAR) T therapy have led to great interest in the possibility of using engineered T-cell receptor (TCR) and CAR T therapies to treat solid tumours. RECENT FINDINGS: In this article, we focus on the published clinical data for engineered TCR and CAR T therapy in solid tumours and recent preclinical work to explore how these therapies may develop and improvE We discuss recent approaches in target selection, encouraging epitope spreading and replicative capacity, CAR activation, T-cell trafficking, survival in the immunosuppressive microenvironment, universal T-cell therapies, manufacturing processes and managing toxicity. SUMMARY: In haematological malignancies, CAR T treatments have shown remarkable clinical responseS Engineered TCR and CAR therapies demonstrate responses in numerous preclinical models of solid tumours and have shown objective clinical responses in select solid tumour types. It is anticipated that the integration of efficacious changes to the T-cell products from disparate preclinical experiments will increase the ability of T-cell therapies to overcome the challenges of treating solid tumours and note that healthcare facilities will need to adapt to deliver these treatments.
    Citation
    Azizi AA, Pillai M, Thistlethwaite FC. T-cell receptor and chimeric antigen receptor in solid cancers: current landscape, preclinical data and insight into future developments. Curr Opin Oncol. 2019;31(5):430-8.
    Journal
    Current Opinion in Oncology
    URI
    http://hdl.handle.net/10541/622041
    DOI
    10.1097/CCO.0000000000000562
    PubMed ID
    31335828
    Additional Links
    https://dx.doi.org/10.1097/CCO.0000000000000562
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1097/CCO.0000000000000562
    Scopus Count
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    All Christie Publications

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