AffiliationUniversity of Manchester, Manchester Academic Health Science Centre, Department 58, Christie Hospital, Manchester M20 4BX, UK
MetadataShow full item record
AbstractHighlights •Oxygen fixes DNA damage by free radicals and cells are 2–3 times more radioresistant to sparsely ionising radiation when irradiated in the absence of oxygen. •OER, the ratio of radiation dose in hypoxia divided by radiation dose in air to produce the same biological effect, decreases with increasing LET. •Reoxygenation occurs during a course of fractionated radiotherapy making tumours cells more sensitive to radiation. •All solid tumour have some level of hypoxia that promotes angiogenesis and metastasis – it is associated with an aggressive phenotype. •High levels of tumour hypoxia are associated with a poor prognosis, hypoxia modification strategies are effective and patients with the most hypoxic tumours benefit most from hypoxia modifying treatments.
CitationWest CM, Slevin F. Tumour hypoxia. Clin Oncol. 2019;31(9):595-9.
- Response of tumour cells to hypoxia: role of p53 and NFkB.
- Authors: Royds JA, Dower SK, Qwarnstrom EE, Lewis CE
- Issue date: 1998 Apr
- Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer.
- Authors: Farina AR, Cappabianca L, Sebastiano M, Zelli V, Guadagni S, Mackay AR
- Issue date: 2020 Jun 15
- [Vascular perfusion as the origin of neoplasm resistance to radio- and chemotherapy].
- Authors: Martinive P, Coucke PA
- Issue date: 2010 Mar
- Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours.
- Authors: Toffoli S, Michiels C
- Issue date: 2008 Jun
- Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients.
- Authors: Bourigault P, Skwarski M, Macpherson RE, Higgins GS, McGowan DR
- Issue date: 2021 Dec 29