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    A challenging presentation of invasive nasopharyngeal sarcomatoid carcinoma

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    Authors
    Yao, A
    Saeed, H
    Udall, G
    Kaushik, V
    Lee, Lip W
    Affiliation
    Department of Otolaryngology, Stockport NHS Foundation Trust, Stockport, UK
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Sarcomatoid carcinoma is a rare clinical entity, especially when presenting in the nasopharynx. We describe the first documented case of nasopharyngeal sarcomatoid carcinoma with intracranial extension in a 59-year-old Caucasian man presenting with severe bifrontal headache and diplopia, secondary to left abducens nerve palsy. We highlight some of the major diagnostic challenges and describe its unusual histological appearance. We outline the importance of a multidisciplinary approach to his management, which includes input from the medicine, neurosurgery, Ear, Nose and Throat (ENT), pathology, radiology, oncology and respiratory teams. In the context of limited evidence, we then describe the rationale to proceed with induction chemotherapy followed by concurrent chemoradiotherapy. Although there was a partial response to treatment, it was not sufficient enough to allow subsequent surgical clearance. The plan going forward is to palliate with chemotherapy as and when the disease progresses.
    Citation
    Yao A, Saeed H, Udall G, Kaushik V, Lee LW. A challenging presentation of invasive nasopharyngeal sarcomatoid carcinoma. BMJ Case Rep. 2019;12(7).
    Journal
    BMJ Case Reports
    URI
    http://hdl.handle.net/10541/622029
    DOI
    10.1136/bcr-2018-226168
    PubMed ID
    31289153
    Additional Links
    https://dx.doi.org/10.1136/bcr-2018-226168
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1136/bcr-2018-226168
    Scopus Count
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