• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    e201900425.full.pdf
    Size:
    5.085Mb
    Format:
    PDF
    Description:
    Full text, Open Access article
    Download
    Authors
    Matsumura, Y
    Ito, Y
    Mezawa, Y
    Sulidan, K
    Daigo, Y
    Hiraga, T
    Mogushi, K
    Wali, N
    Suzuki, H
    Itoh, T
    Miyagi, Y
    Yokose, T
    Shimizu, S
    Takano, A
    Terao, Y
    Saeki, H
    Ozawa, M
    Abe, M
    Takeda, S
    Okumura, K
    Habu, S
    Hino, O
    Takeda, K
    Hamada, M
    Orimo, Akira
    Show allShow less
    Affiliation
    Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Emerging evidence supports the hypothesis that multicellular tumor clusters invade and seed metastasis. However, whether tumor-associated stroma induces epithelial-mesenchymal plasticity in tumor cell clusters, to promote invasion and metastasis, remains unknown. We demonstrate herein that carcinoma-associated fibroblasts (CAFs) frequently present in tumor stroma drive the formation of tumor cell clusters composed of two distinct cancer cell populations, one in a highly epithelial (E-cadherin(hi)ZEB1(lo/neg): E(hi)) state and another in a hybrid epithelial/mesenchymal (E-cadherin(lo)ZEB1(hi): E/M) state. The E(hi) cells highly express oncogenic cell-cell adhesion molecules, such as carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and CEACAM6 that associate with E-cadherin, resulting in increased tumor cell cluster formation and metastatic seeding. The E/M cells also retain associations with E(hi) cells, which follow the E/M cells leading to collective invasion. CAF-produced stromal cell-derived factor 1 and transforming growth factor-beta confer the E(hi) and E/M states as well as invasive and metastatic traits via Src activation in apposed human breast tumor cells. Taken together, these findings indicate that invasive and metastatic tumor cell clusters are induced by CAFs via epithelial-mesenchymal plasticity.
    Citation
    Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, et al. Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity. Life Sci Alliance. 2019 Aug;2(4).
    Journal
    Life Science Alliance
    URI
    http://hdl.handle.net/10541/621986
    DOI
    10.26508/lsa.201900425
    PubMed ID
    31331982
    Additional Links
    https://dx.doi.org/10.26508/lsa.201900425
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.26508/lsa.201900425
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state.
    • Authors: Mizukoshi K, Okazawa Y, Haeno H, Koyama Y, Sulidan K, Komiyama H, Saeki H, Ohtsuji N, Ito Y, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K, Orimo A
    • Issue date: 2020 May 1
    • Glypican-3 induces a mesenchymal to epithelial transition in human breast cancer cells.
    • Authors: Castillo LF, Tascón R, Lago Huvelle MR, Novack G, Llorens MC, Dos Santos AF, Shortrede J, Cabanillas AM, Bal de Kier Joffé E, Labriola L, Peters MG
    • Issue date: 2016 Sep 13
    • NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype.
    • Authors: Bocci F, Tripathi SC, Vilchez Mercedes SA, George JT, Casabar JP, Wong PK, Hanash SM, Levine H, Onuchic JN, Jolly MK
    • Issue date: 2019 Jun 1
    • CEACAM6 promotes gastric cancer invasion and metastasis by inducing epithelial-mesenchymal transition via PI3K/AKT signaling pathway.
    • Authors: Zang M, Zhang B, Zhang Y, Li J, Su L, Zhu Z, Gu Q, Liu B, Yan M
    • Issue date: 2014
    • Zinc Finger E-Box Binding Homeobox 1 Promotes Cholangiocarcinoma Progression Through Tumor Dedifferentiation and Tumor-Stroma Paracrine Signaling.
    • Authors: Lobe C, Vallette M, Arbelaiz A, Gonzalez-Sanchez E, Izquierdo L, Pellat A, Guedj N, Louis C, Paradis V, Banales JM, Coulouarn C, Housset C, Vaquero J, Fouassier L
    • Issue date: 2021 Dec
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.