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dc.contributor.authorPonzetta, A
dc.contributor.authorCarriero, R
dc.contributor.authorCarnevale, S
dc.contributor.authorBarbagallo, M
dc.contributor.authorMolgora, M
dc.contributor.authorPerucchini, C
dc.contributor.authorMagrini, E
dc.contributor.authorGianni, F
dc.contributor.authorKunderfranco, P
dc.contributor.authorPolentarutti, N
dc.contributor.authorPasqualini, F
dc.contributor.authorDi Marco, S
dc.contributor.authorSupino, D
dc.contributor.authorPeano, C
dc.contributor.authorCananzi, F
dc.contributor.authorColombo, P
dc.contributor.authorPilotti, S
dc.contributor.authorAlomar, SY
dc.contributor.authorBonavita, Eduardo
dc.contributor.authorGaldiero, MR
dc.contributor.authorGarlanda, C
dc.contributor.authorMantovani, A
dc.contributor.authorJaillon, S
dc.date.accessioned2019-09-11T09:09:12Z
dc.date.available2019-09-11T09:09:12Z
dc.date.issued2019en
dc.identifier.citationPonzetta A, Carriero R, Carnevale S, Barbagallo M, Molgora M, Perucchini C, et al. Neutrophils driving unconventional T cells mediate resistance against murine sarcomas and selected human tumors. Cell. 2019 Jul 11;178(2):346-60 e24.en
dc.identifier.pmid31257026en
dc.identifier.doi10.1016/j.cell.2019.05.047en
dc.identifier.urihttp://hdl.handle.net/10541/621982
dc.description.abstractNeutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented by adoptive transfer, we found that neutrophils are essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. Neutrophils were essential for the activation of an interferon-gamma-dependent pathway of immune resistance, associated with polarization of a subset of CD4(-) CD8(-) unconventional alphabeta T cells (UTCalphabeta). Bulk and single-cell RNA sequencing (scRNA-seq) analyses unveiled the innate-like features and diversity of UTCalphabeta associated with neutrophil-dependent anti-sarcoma immunity. In selected human tumors, including undifferentiated pleomorphic sarcoma, CSF3R expression, a neutrophil signature and neutrophil infiltration were associated with a type 1 immune response and better clinical outcome. Thus, neutrophils driving UTCalphabeta polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.cell.2019.05.047en
dc.titleNeutrophils driving unconventional T cells mediate resistance against murine sarcomas and selected human tumorsen
dc.typeArticleen
dc.contributor.departmentDepartment of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italyen
dc.identifier.journalCellen
dc.description.noteen]
refterms.dateFOA2019-09-21T19:41:28Z


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