Neutrophils driving unconventional T cells mediate resistance against murine sarcomas and selected human tumors
dc.contributor.author | Ponzetta, A | |
dc.contributor.author | Carriero, R | |
dc.contributor.author | Carnevale, S | |
dc.contributor.author | Barbagallo, M | |
dc.contributor.author | Molgora, M | |
dc.contributor.author | Perucchini, C | |
dc.contributor.author | Magrini, E | |
dc.contributor.author | Gianni, F | |
dc.contributor.author | Kunderfranco, P | |
dc.contributor.author | Polentarutti, N | |
dc.contributor.author | Pasqualini, F | |
dc.contributor.author | Di Marco, S | |
dc.contributor.author | Supino, D | |
dc.contributor.author | Peano, C | |
dc.contributor.author | Cananzi, F | |
dc.contributor.author | Colombo, P | |
dc.contributor.author | Pilotti, S | |
dc.contributor.author | Alomar, SY | |
dc.contributor.author | Bonavita, Eduardo | |
dc.contributor.author | Galdiero, MR | |
dc.contributor.author | Garlanda, C | |
dc.contributor.author | Mantovani, A | |
dc.contributor.author | Jaillon, S | |
dc.date.accessioned | 2019-09-11T09:09:12Z | |
dc.date.available | 2019-09-11T09:09:12Z | |
dc.date.issued | 2019 | en |
dc.identifier.citation | Ponzetta A, Carriero R, Carnevale S, Barbagallo M, Molgora M, Perucchini C, et al. Neutrophils driving unconventional T cells mediate resistance against murine sarcomas and selected human tumors. Cell. 2019 Jul 11;178(2):346-60 e24. | en |
dc.identifier.pmid | 31257026 | en |
dc.identifier.doi | 10.1016/j.cell.2019.05.047 | en |
dc.identifier.uri | http://hdl.handle.net/10541/621982 | |
dc.description.abstract | Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented by adoptive transfer, we found that neutrophils are essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. Neutrophils were essential for the activation of an interferon-gamma-dependent pathway of immune resistance, associated with polarization of a subset of CD4(-) CD8(-) unconventional alphabeta T cells (UTCalphabeta). Bulk and single-cell RNA sequencing (scRNA-seq) analyses unveiled the innate-like features and diversity of UTCalphabeta associated with neutrophil-dependent anti-sarcoma immunity. In selected human tumors, including undifferentiated pleomorphic sarcoma, CSF3R expression, a neutrophil signature and neutrophil infiltration were associated with a type 1 immune response and better clinical outcome. Thus, neutrophils driving UTCalphabeta polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors. | en |
dc.language.iso | en | en |
dc.relation.url | https://dx.doi.org/10.1016/j.cell.2019.05.047 | en |
dc.title | Neutrophils driving unconventional T cells mediate resistance against murine sarcomas and selected human tumors | en |
dc.type | Article | en |
dc.contributor.department | Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Italy | en |
dc.identifier.journal | Cell | en |
dc.description.note | en] | |
refterms.dateFOA | 2019-09-21T19:41:28Z |