Chemical purification of terbium-155 from pseudo-isobaric impurities in a mass separated source produced at CERN
Name:
s41598-019-47463-3.pdf
Size:
1.641Mb
Format:
PDF
Description:
Full text, Open Access article
Affiliation
National Physical Laboratory, Teddington, TW11 0LW, UKIssue Date
2019
Metadata
Show full item recordAbstract
Four terbium radioisotopes ((149, 152, 155, 161)Tb) constitute a potential theranostic quartet for cancer treatment but require any derived radiopharmaceutical to be essentially free of impurities. Terbium-155 prepared by proton irradiation and on-line mass separation at the CERN-ISOLDE and CERN-MEDICIS facilities contains radioactive (139)Ce(16)O and also zinc or gold, depending on the catcher foil used. A method using ion-exchange and extraction chromatography resins in two column separation steps has been developed to isolate (155)Tb with a chemical yield of >/=95% and radionuclidic purity >/=99.9%. Conversion of terbium into a form suitable for chelation to targeting molecules in diagnostic nuclear medicine is presented. The resulting (155)Tb preparations are suitable for the determination of absolute activity, SPECT phantom imaging studies and pre-clinical trials.Citation
Webster B, Ivanov P, Russell B, Collins S, Stora T, Ramos JP, et al. Chemical purification of terbium-155 from pseudo-isobaric impurities in a mass separated source produced at CERN. Sci Rep. 2019 Jul 26;9(1):10884.Journal
Scientific ReportsDOI
10.1038/s41598-019-47463-3PubMed ID
31350422Additional Links
https://dx.doi.org/10.1038/s41598-019-47463-3Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41598-019-47463-3
Scopus Count
Collections
Related articles
- Terbium-149 production: a focus on yield and quality improvement towards preclinical application.
- Authors: Favaretto C, Grundler PV, Talip Z, Köster U, Johnston K, Busslinger SD, Sprung P, Hillhouse CC, Eichler R, Schibli R, Müller C, van der Meulen NP
- Issue date: 2024 Feb 8
- Future prospects for SPECT imaging using the radiolanthanide terbium-155 - production and preclinical evaluation in tumor-bearing mice.
- Authors: Müller C, Fischer E, Behe M, Köster U, Dorrer H, Reber J, Haller S, Cohrs S, Blanc A, Grünberg J, Bunka M, Zhernosekov K, van der Meulen N, Johnston K, Türler A, Schibli R
- Issue date: 2014 May
- CERN-MEDICIS: A Review Since Commissioning in 2017.
- Authors: Duchemin C, Ramos JP, Stora T, Ahmed E, Aubert E, Audouin N, Barbero E, Barozier V, Bernardes AP, Bertreix P, Boscher A, Bruchertseifer F, Catherall R, Chevallay E, Christodoulou P, Chrysalidis K, Cocolios TE, Comte J, Crepieux B, Deschamps M, Dockx K, Dorsival A, Fedosseev VN, Fernier P, Formento-Cavaier R, El Idrissi S, Ivanov P, Gadelshin VM, Gilardoni S, Grenard JL, Haddad F, Heinke R, Juif B, Khalid U, Khan M, Köster U, Lambert L, Lilli G, Lunghi G, Marsh BA, Palenzuela YM, Martins R, Marzari S, Menaa N, Michel N, Munos M, Pozzi F, Riccardi F, Riegert J, Riggaz N, Rinchet JY, Rothe S, Russell B, Saury C, Schneider T, Stegemann S, Talip Z, Theis C, Thiboud J, van der Meulen NP, van Stenis M, Vincke H, Vollaire J, Vuong NT, Webster B, Wendt K, Wilkins SG, CERN-MEDICIS collaboration
- Issue date: 2021
- Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging.
- Authors: Favaretto C, Talip Z, Borgna F, Grundler PV, Dellepiane G, Sommerhalder A, Zhang H, Schibli R, Braccini S, Müller C, van der Meulen NP
- Issue date: 2021 Nov 14
- A unique matched quadruplet of terbium radioisotopes for PET and SPECT and for α- and β- radionuclide therapy: an in vivo proof-of-concept study with a new receptor-targeted folate derivative.
- Authors: Müller C, Zhernosekov K, Köster U, Johnston K, Dorrer H, Hohn A, van der Walt NT, Türler A, Schibli R
- Issue date: 2012 Dec