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    Chemical purification of terbium-155 from pseudo-isobaric impurities in a mass separated source produced at CERN

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    Authors
    Webster, B
    Ivanov, P
    Russell, B
    Collins, S
    Stora, T
    Ramos, JP
    Koster, U
    Robinson, Andrew P
    Read, D
    Affiliation
    National Physical Laboratory, Teddington, TW11 0LW, UK
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Four terbium radioisotopes ((149, 152, 155, 161)Tb) constitute a potential theranostic quartet for cancer treatment but require any derived radiopharmaceutical to be essentially free of impurities. Terbium-155 prepared by proton irradiation and on-line mass separation at the CERN-ISOLDE and CERN-MEDICIS facilities contains radioactive (139)Ce(16)O and also zinc or gold, depending on the catcher foil used. A method using ion-exchange and extraction chromatography resins in two column separation steps has been developed to isolate (155)Tb with a chemical yield of >/=95% and radionuclidic purity >/=99.9%. Conversion of terbium into a form suitable for chelation to targeting molecules in diagnostic nuclear medicine is presented. The resulting (155)Tb preparations are suitable for the determination of absolute activity, SPECT phantom imaging studies and pre-clinical trials.
    Citation
    Webster B, Ivanov P, Russell B, Collins S, Stora T, Ramos JP, et al. Chemical purification of terbium-155 from pseudo-isobaric impurities in a mass separated source produced at CERN. Sci Rep. 2019 Jul 26;9(1):10884.
    Journal
    Scientific Reports
    URI
    http://hdl.handle.net/10541/621967
    DOI
    10.1038/s41598-019-47463-3
    PubMed ID
    31350422
    Additional Links
    https://dx.doi.org/10.1038/s41598-019-47463-3
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-019-47463-3
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