Phenotype plasticity as enabler of melanoma progression and therapy resistance
Affiliation
Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, SpainIssue Date
2019
Metadata
Show full item recordAbstract
Malignant melanoma is notorious for its inter- and intratumour heterogeneity, based on transcriptionally distinct melanoma cell phenotypes. It is thought that these distinct phenotypes are plastic in nature and that their transcriptional reprogramming enables heterogeneous tumours both to undergo different stages of melanoma progression and to adjust to drug exposure during treatment. Recent advances in genomic technologies and the rapidly expanding availability of large gene expression datasets have allowed for a refined definition of the gene signatures that characterize these phenotypes and have revealed that phenotype plasticity plays a major role in the resistance to both targeted therapy and immunotherapy. In this Review we discuss the definition of melanoma phenotypes through particular transcriptional states and reveal the prognostic relevance of the related gene expression signatures. We review how the establishment of phenotypes is controlled and which roles phenotype plasticity plays in melanoma development and therapy. Because phenotype plasticity in melanoma bears a great resemblance to epithelial-mesenchymal transition, the lessons learned from melanoma will also benefit our understanding of other cancer types.Citation
Arozarena I, Wellbrock C. Phenotype plasticity as enabler of melanoma progression and therapy resistance. Nat Rev Cancer. 2019 Jul;19(7):377-91.Journal
Nature Reviews. CancerDOI
10.1038/s41568-019-0154-4PubMed ID
31209265Additional Links
https://dx.doi.org/10.1038/s41568-019-0154-4Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41568-019-0154-4
Scopus Count
Collections
Related articles
- Cooperative behaviour and phenotype plasticity evolve during melanoma progression.
- Authors: Rowling EJ, Miskolczi Z, Nagaraju R, Wilcock DJ, Wang P, Telfer B, Li Y, Lasheras-Otero I, Redondo-Muñoz M, Sharrocks AD, Arozarena I, Wellbrock C
- Issue date: 2020 Sep
- Transcriptional signatures underlying dynamic phenotypic switching and novel disease biomarkers in a linear cellular model of melanoma progression.
- Authors: Pessoa DO, Rius FE, Papaiz DD, Ayub ALP, Morais AS, de Souza CF, da Paixão VF, Setubal JC, Newton-Bishop J, Nsengimana J, Azevedo H, Reis EM, Jasiulionis MG
- Issue date: 2021 Apr
- Phenotype Switching and the Melanoma Microenvironment; Impact on Immunotherapy and Drug Resistance.
- Authors: Hossain SM, Eccles MR
- Issue date: 2023 Jan 13
- Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma.
- Authors: Roesch A, Paschen A, Landsberg J, Helfrich I, Becker JC, Schadendorf D
- Issue date: 2016 May
- Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.
- Authors: Falletta P, Sanchez-Del-Campo L, Chauhan J, Effern M, Kenyon A, Kershaw CJ, Siddaway R, Lisle R, Freter R, Daniels MJ, Lu X, Tüting T, Middleton M, Buffa FM, Willis AE, Pavitt G, Ronai ZA, Sauka-Spengler T, Hölzel M, Goding CR
- Issue date: 2017 Jan 1