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    REQUITE: a prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

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    Authors
    Seibold, P
    Webb, A
    Aguado-Barrera, M. E.
    Azria, D
    Bourgier, C
    Brengues, M
    Briers, E
    Bultijnck, R
    Calvo-Crespo, P
    Carballo, A
    Choudhury, Ananya
    Cicchetti, A
    Classen, J
    Delmastro, E
    Dunning, AM
    Elliott, RM
    Farcy-Jacquet, MP
    Gabriele, P
    Garibaldi, E
    Gomez-Caamano, A
    Gutierrez-Enriquez, S
    Higginson, DS
    Johnson, K
    Lobato-Busto, R
    Molla, M
    Muller, A
    Payne, D
    Peleteiro, P
    Post, G
    Rancati, T
    Rattay, T
    Reyes, V
    Rosenstein, BS
    De, RD
    De Santis, MC
    Schafer, J
    Schnabel, T
    Sperk, E
    Symonds, RP
    Stobart, H
    Taboada-Valladares, B
    Talbot, CJ
    Valdagni, R
    Vega, A
    Veldeman, L
    Ward, T
    Weissenberger, C
    West, Catharine M L
    Chang-Claude, J
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    Affiliation
    Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    PURPOSE: REQUITE aimed to establish a resource for multi-national validation of models and biomarkers that predict risk of late toxicity following radiotherapy. The purpose of this article is to provide summary descriptive data. METHODS: An international, prospective cohort study recruited cancer patients in 26 hospitals in eight countries between April 2014 and March 2017. Target recruitment was 5300 patients. Eligible patients had breast, prostate or lung cancer and planned potentially curable radiotherapy. Radiotherapy was prescribed according to local regimens, but centres used standardised data collection forms. Pre-treatment blood samples were collected. Patients were followed for a minimum of 12 (lung) or 24 (breast/prostate) months and summary descriptive statistics were generated. RESULTS: The study recruited 2069 breast (99% of target), 1808 prostate (86%) and 561 lung (51%) cancer patients. The centralised, accessible database includes: physician- (47,025 forms) and patient- (54,901) reported outcomes; 11,563 breast photos; 17,107 DICOMs and 12,684 DVHs. Imputed genotype data are available for 4223 patients with European ancestry (1948 breast, 1728 prostate, 547 lung). Radiation-induced lymphocyte apoptosis (RILA) assay data are available for 1319 patients. DNA (n?=?4409) and PAXgene tubes (n?=?3039) are stored in the centralised biobank. Example prevalences of 2-year (1-year for lung) grade ³2 CTCAE toxicities are 13% atrophy (breast), 3% rectal bleeding (prostate) and 27% dyspnoea (lung). CONCLUSION: The comprehensive centralised database and linked biobank is a valuable resource for the radiotherapy community for validating predictive models and biomarkers. PATIENT SUMMARY: Up to half of cancer patients undergo radiation therapy and irradiation of surrounding healthy tissue is unavoidable. Damage to healthy tissue can affect short- and long-term quality-of-life. Not all patients are equally sensitive to radiation "damage" but it is not possible at the moment to identify those who are. REQUITE was established with the aim of trying to understand more about how we could predict radiation sensitivity. The purpose of this paper is to provide an overview and summary of the data and material available. In the REQUITE study 4400 breast, prostate and lung cancer patients filled out questionnaires and donated blood. A large amount of data was collected in the same way. With all these data and samples a database and biobank were created that showed it is possible to collect this kind of information in a standardised way across countries. In the future, our database and linked biobank will be a resource for research and validation of clinical predictors and models of radiation sensitivity. REQUITE will also enable a better understanding of how many people suffer with radiotherapy toxicity.
    Citation
    Seibold P, Webb A, Aguado-Barrera ME, Azria D, Bourgier C, Brengues M, et al. REQUITE: a prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer. Radiother Oncol. 2019 May 27;138:59-67.
    Journal
    Radiotherapy and Oncology
    URI
    http://hdl.handle.net/10541/621951
    DOI
    10.1016/j.radonc.2019.04.034
    PubMed ID
    31146072
    Additional Links
    https://dx.doi.org/10.1016/j.radonc.2019.04.034
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.radonc.2019.04.034
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