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    Efficacy and safety of a bortezomib and reduced-intensity cytarabine-based protocol, TMC ALLR1, for relapsed childhood ALL in India

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    Authors
    Roy, P
    Islam, R
    Saha, D
    Gogoi, M
    Kumar, MD
    Arora, N
    Parihar, M
    Krishnan, Shekhar
    Saha, Vaskar
    Affiliation
    Department of Paediatric Haematology Oncology, Tata Translational Cancer Research Centre, Tata Medical Centre, Kolkata, India
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    The feasibility of bortezomib (BZB) in induction and reduced cytarabine doses in intensification was evaluated in children with relapsed acute lymphoblastic leukaemia (rALL) at a single centre in India. Of 55 children with rALL, 23 received supportive care and 7 refused treatment, with a median survival of 2 (interquartile range 1-6) months. Twenty-two (88%) of 25 children who were treated achieved second remission and 9 (69%) of 13 had end-of-induction minimal residual disease of <10-4 . The lower cytarabine dose was associated with decreased hospitalisation. One-year event-free and overall survival for the treated group was 74á7% (95% confidence interval 52-88) and 79á6% (58-91) respectively.
    Citation
    Roy P, Islam R, Saha D, Gogoi M, Kumar Mishra D, Arora N, et al. Efficacy and safety of a bortezomib and reduced-intensity cytarabine-based protocol, TMC ALLR1, for relapsed childhood ALL in India. Br J Haematol. 2019 Jun 5.
    Journal
    British Journal of Haematology
    URI
    http://hdl.handle.net/10541/621946
    DOI
    10.1111/bjh.16005
    PubMed ID
    31168836
    Additional Links
    https://dx.doi.org/10.1111/bjh.16005
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1111/bjh.16005
    Scopus Count
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