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    Asymmetric inheritance of cell fate determinants: focus on RNA

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    Authors
    Shlyakhtina, Yelyzaveta
    Moran, Katherine L
    Portal, Maximiliano M
    Affiliation
    Cell Plasticity & Epigenetics Lab, Cancer Research UK(-)Manchester Institute, The University of Manchester, SK10 4TG Manchester, UK.
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    During the last decade, and mainly primed by major developments in high-throughput sequencing technologies, the catalogue of RNA molecules harbouring regulatory functions has increased at a steady pace. Current evidence indicates that hundreds of mammalian RNAs have regulatory roles at several levels, including transcription, translation/post-translation, chromatin structure, and nuclear architecture, thus suggesting that RNA molecules are indeed mighty controllers in the flow of biological information. Therefore, it is logical to suggest that there must exist a series of molecular systems that safeguard the faithful inheritance of RNA content throughout cell division and that those mechanisms must be tightly controlled to ensure the successful segregation of key molecules to the progeny. Interestingly, whilst a handful of integral components of mammalian cells seem to follow a general pattern of asymmetric inheritance throughout division, the fate of RNA molecules largely remains a mystery. Herein, we will discuss current concepts of asymmetric inheritance in a wide range of systems, including prions, proteins, and finally RNA molecules, to assess overall the biological impact of RNA inheritance in cellular plasticity and evolutionary fitness.
    Citation
    Shlyakhtina Y, Moran KL, Portal MM. Asymmetric inheritance of cell fate determinants: Focus on RNA. Noncoding RNA. 2019 May 9;5(2).
    Journal
    Non-coding RNA
    URI
    http://hdl.handle.net/10541/621916
    DOI
    10.3390/ncrna5020038
    PubMed ID
    31075989
    Additional Links
    https://dx.doi.org/10.3390/ncrna5020038
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.3390/ncrna5020038
    Scopus Count
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    All Paterson Institute for Cancer Research

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