Show simple item record

dc.contributor.authorMolloy, K
dc.contributor.authorJonak, C
dc.contributor.authorWoei, AJF
dc.contributor.authorGuenova, E
dc.contributor.authorBusschots, AM
dc.contributor.authorBervoets, A
dc.contributor.authorHauben, E
dc.contributor.authorKnobler, R
dc.contributor.authorPorkert, S
dc.contributor.authorFassnacht, C
dc.contributor.authorCowan, Richard A
dc.contributor.authorPapadavid, E
dc.contributor.authorBeylot-Barry, M
dc.contributor.authorBerti, E
dc.contributor.authorAlberti, VS
dc.contributor.authorEstrach, T
dc.contributor.authorMatin, R
dc.contributor.authorAkilov, O
dc.contributor.authorVakeva, L
dc.contributor.authorPrince, M
dc.contributor.authorBates, A
dc.contributor.authorBayne, M
dc.contributor.authorWachsmuch, R
dc.contributor.authorWehkamp, U
dc.contributor.authorMarschalko, M
dc.contributor.authorServitje, O
dc.contributor.authorTurner, D
dc.contributor.authorWeatherhead, S
dc.contributor.authorWobser, M
dc.contributor.authorSanches, JA
dc.contributor.authorMcKay, P
dc.contributor.authorKlemke, D
dc.contributor.authorPeng, C
dc.contributor.authorHowles, A
dc.contributor.authorYoo, J
dc.contributor.authorEvison, F
dc.contributor.authorScarisbrick, J
dc.date.accessioned2019-06-25T09:32:58Z
dc.date.available2019-06-25T09:32:58Z
dc.date.issued2019en
dc.identifier.citationMolloy K, Jonak C, Woei AJF, Guenova E, Busschots AM, Bervoets A, et al. Characteristics associated with significantly worse quality of life in mycosis fungoides/Sezary syndrome from the Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) study. Br J Dermatol. 2019 May 2.en
dc.identifier.pmid31049926en
dc.identifier.doi10.1111/bjd.18089en
dc.identifier.urihttp://hdl.handle.net/10541/621909
dc.description.abstractBACKGROUND: Mycosis fungoides (MF) and Sézary Syndrome (SS) are the most common cutaneous T-cell lymphomas. MF/SS is accompanied by considerable morbidity from pain, itching and disfigurement. AIM: To identify factors associated with poorer health-related quality of life (HRQoL) in newly diagnosed MF/SS patients. METHODS: Patients enrolled into PROCLIPI (an international observational study in MF/SS) had HRQoL assessed using the Skindex-29 questionnaire. Skindex-29 scores were analysed in relation to patient-specific and disease-specific characteristics. RESULTS: The study population consisted of 237 patients (60·3% male) with a median age of 60 years (IQR 49-70yrs), of whom 179 had early MF and 58 had advanced MF/SS. In univariate analysis, HRQoL as measured by Skindex-29 was worse in females, SS, late-stage MF, those with elevated LDH, alopecia, high mSWAT and confluent erythema. Linear regression models only identified female gender (?=8·61, p=0·003) and alopecia (?=9·71, p=0·02) as independent predictors for worse global HRQoL. In item-level analysis showed that the severe impairment in symptoms (OR 2·14, 95% CI 1·19-3·89) and emotions (OR 1·88, 95% CI 1·09-3·27) subscale scores seen in female patients was caused by more burning/stinging, pruritus, irritation and greater feelings of depression, shame, embarrassment and annoyance with their diagnosis of MF/SS. CONCLUSION: HRQoL is significantly more impaired in newly diagnosed female patients with MF/SS and in those with alopecia. As Skindex-29 does not include existential questions on cancer which may cause additional worry and distress, a comprehensive validated CTCL specific questionnaire is urgently needed to more accurately assess disease-specific HRQoL among these patients. This article is protected by copyright. All rights reserved.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1111/bjd.18089en
dc.titleCharacteristics associated with significantly worse quality of life in mycosis fungoides/Sezary syndrome from the Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) studyen
dc.typeArticleen
dc.contributor.departmentUniversity Hospitals Birmingham, UKen
dc.identifier.journalThe British Journal of Dermatologyen
dc.description.noteen]


This item appears in the following Collection(s)

Show simple item record