Association analyses identify 31 new risk loci for colorectal cancer susceptibility
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Authors
Law, PTimofeeva, M
Fernandez-Rozadilla, C
Broderick, P
Studd, J
Fernandez-Tajes, J
Farrington, S
Svinti, V
Palles, C
Orlando, G
Sud, A
Holroyd, A
Penegar, S
Theodoratou, E
Vaughan-Shaw, P
Campbell, H
Zgaga, L
Hayward, C
Campbell, A
Harris, S
Deary, I
Starr, J
Gatcombe, L
Pinna, M
Briggs, S
Martin, L
Jaeger, E
Sharma-Oates, A
East, J
Leedham, S
Arnold, R
Johnstone, E
Wang, H
Kerr, D
Kerr, R
Maughan, T
Kaplan, R
Al-Tassan, N
Palin, K
Hanninen, U
Cajuso, T
Tanskanen, T
Kondelin, J
Kaasinen, E
Sarin, A
Eriksson, J
Rissanen, H
Knekt, P
Pukkala, E
Jousilahti, P
Salomaa, V
Ripatti, S
Palotie, A
Renkonen-Sinisalo, L
Lepisto, A
Bohm, J
Mecklin, J
Buchanan, D
Win, A
Hopper, J
Jenkins, M
Lindor, N
Newcomb, P
Gallinger, S
Duggan, D
Casey, G
Hoffmann, P
Nothen, M
Jockel, K
Easton, D
Pharoah, P
Peto, J
Canzian, F
Swerdlow, A
Eeles, R
Kote-Jarai, Z
Muir, K
Pashayan, N
Harkin, A
Allan, K
McQueen, J
Paul, J
Iveson, T
Saunders, Mark P
Butterbach, K
Chang-Claude, J
Hoffmeister, M
Brenner, H
Kirac, I
Matosevic, P
Hofer, P
Brezina, S
Gsur, A
Cheadle, J
Aaltonen, L
Tomlinson, I
Houlston, R
Dunlop, M
Affiliation
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, SW7 3RP, UKIssue Date
2019
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Show full item recordAbstract
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.Citation
Law PJ, Timofeeva M, Fernandez-Rozadilla C, Broderick P, Studd J, Fernandez-Tajes J, et al. Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nat Commun. 2019;10(1):2154.Journal
Nature CommunicationsDOI
10.1038/s41467-019-09775-wPubMed ID
31089142Additional Links
https://dx.doi.org/10.1038/s41467-019-09775-wType
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1038/s41467-019-09775-w