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    Formidable scenarios in urothelial and variant cancers of the urinary tract

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    Authors
    Aragon-Ching, J
    Choudhury, Ananya
    Margulis, V
    Yu, E
    Affiliation
    Inova Schar Cancer Institute, Fairfax, VA2 The Christie National Health Service Foundation Trust, Manchester, United Kingdom
    Issue Date
    2019
    
    Metadata
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    Abstract
    Diagnostic and therapeutic challenges in the field of bladder and upper tract cancers provide opportunities for multidisciplinary care. Urothelial cancers make up the majority of the histologic subtype of bladder and upper tract cancers. Although the existence of variant histology, nonurothelial cancers, and urethral cancers is rare, these cancers pose a challenging clinical dilemma given the lack of well-defined consensus treatment guidelines. This review focuses on key issues of treatment: cisplatin ineligibility with emphasis on the definition, nuances of chemotherapy and frontline immune checkpoint inhibitor therapy, use of radiation in bladder-preservation strategies, upper tract urothelial cancer management, and highlights of urothelial variants and nonurothelial tumors and management.
    Citation
    Aragon-Ching JB, Choudhury A, Margulis V, Yu EY. Formidable scenarios in urothelial and variant cancers of the urinary tract. Am Soc Clin Oncol Educ Book. 2019;39:262-75.
    Journal
    American Society of Clinical Oncology Educational Book
    URI
    http://hdl.handle.net/10541/621897
    DOI
    10.1200/EDBK_237451
    PubMed ID
    31099661
    Additional Links
    https://dx.doi.org/10.1200/EDBK_237451
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1200/EDBK_237451
    Scopus Count
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    All Christie Publications

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