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dc.contributor.authorPrice, Emlyn
dc.contributor.authorTipping, Jill
dc.contributor.authorCullen, D
dc.contributor.authorCalvert, Nicholas
dc.contributor.authorHamilton, David
dc.contributor.authorPage, Emma
dc.contributor.authorPells, S
dc.contributor.authorPietras, B
dc.contributor.authorRobinson, A
dc.date.accessioned2019-06-25T09:32:53Z
dc.date.available2019-06-25T09:32:53Z
dc.date.issued2019en
dc.identifier.citationPrice E, Tipping J, Cullen DM, Calvert N, Hamilton D, Page E, et al. Positional dependence of activity determination in single photon emission computed tomography. Nucl Med Commun. 2019.en
dc.identifier.pmid31136536en
dc.identifier.doi10.1097/MNM.0000000000001034en
dc.identifier.urihttp://hdl.handle.net/10541/621887
dc.description.abstractAccurate image quantification requires accurate calibration of the detector and is vital if dosimetry is to be performed in molecular radiotherapy. A dependence on the position of calibration has been observed in single photon emission computed tomography images when attenuation correction (AC) and scatter correction are applied. This work investigates the origin of this dependence in single photon emission computed tomography scans of phantom inserts filled with Lu solution. A 113?ml sphere and inserts representing a mathematical model of a spleen and an anatomical model of a patient spleen were imaged at the centre and edge of elliptical phantoms. For these inserts, the difference in calibration factor between the positions was around 10% for images reconstructed with AC and triple energy window scatter correction. A combination of experimental imaging and Monte Carlo simulation was used to isolate possible causes due to imaging or reconstruction in turn. Inconsistent application of AC between different reconstruction systems was identified as the origin of the positional dependence.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1097/MNM.0000000000001034en
dc.titlePositional dependence of activity determination in single photon emission computed tomographyen
dc.typeArticleen
dc.contributor.departmentSchuster Laboratory, School of Physics and Astronomy, The University of Manchester Christie Medical Physics and Engineering (CMPE), Manchesteren
dc.identifier.journalNuclear Medicine Communicationsen
dc.description.noteen]
refterms.dateFOA2019-06-27T15:01:28Z


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