Positional dependence of activity determination in single photon emission computed tomography
AffiliationSchuster Laboratory, School of Physics and Astronomy, The University of Manchester Christie Medical Physics and Engineering (CMPE), Manchester
MetadataShow full item record
AbstractAccurate image quantification requires accurate calibration of the detector and is vital if dosimetry is to be performed in molecular radiotherapy. A dependence on the position of calibration has been observed in single photon emission computed tomography images when attenuation correction (AC) and scatter correction are applied. This work investigates the origin of this dependence in single photon emission computed tomography scans of phantom inserts filled with Lu solution. A 113?ml sphere and inserts representing a mathematical model of a spleen and an anatomical model of a patient spleen were imaged at the centre and edge of elliptical phantoms. For these inserts, the difference in calibration factor between the positions was around 10% for images reconstructed with AC and triple energy window scatter correction. A combination of experimental imaging and Monte Carlo simulation was used to isolate possible causes due to imaging or reconstruction in turn. Inconsistent application of AC between different reconstruction systems was identified as the origin of the positional dependence.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/.
CitationPrice E, Tipping J, Cullen DM, Calvert N, Hamilton D, Page E, et al. Positional dependence of activity determination in single photon emission computed tomography. Nucl Med Commun. 2019.
JournalNuclear Medicine Communications
- The effect of attenuation map, scatter energy window width, and volume of interest on the calibration factor calculation in quantitative <sup>177</sup>Lu SPECT imaging: Simulation and phantom study.
- Authors: Karimi Ghodoosi E, D'Alessandria C, Li Y, Bartel A, Köhner M, Höllriegl V, Navab N, Eiber M, Li WB, Frey E, Ziegler S
- Issue date: 2018 Dec
- Impact of missing attenuation and scatter corrections on <sup>99m</sup> Tc-MAA SPECT 3D dosimetry for liver radioembolization using the patient relative calibration methodology: A retrospective investigation on clinical images.
- Authors: Botta F, Ferrari M, Chiesa C, Vitali S, Guerriero F, Nile MC, Mira M, Lorenzon L, Pacilio M, Cremonesi M
- Issue date: 2018 Apr
- Impact of reconstruction parameters on quantitative I-131 SPECT.
- Authors: van Gils CA, Beijst C, van Rooij R, de Jong HW
- Issue date: 2016 Jul 21
- The influence of triple energy window scatter correction on activity quantification for (1 7 7)Lu molecular radiotherapy.
- Authors: Robinson AP, Tipping J, Cullen DM, Hamilton D
- Issue date: 2016 Jul 21
- Correction of nonuniform attenuation and image fusion in SPECT imaging by means of separate X-ray CT.
- Authors: Kashiwagi T, Yutani K, Fukuchi M, Naruse H, Iwasaki T, Yokozuka K, Inoue S, Kondo S
- Issue date: 2002 Jun