RAPPER - A success story for collaborative translational radiotherapy research
Affiliation#Division of Cancer Sciences, University of Manchester, Manchester Cancer Research Centre, Manchester Academic Health Science Centre, Manchester, UK
MetadataShow full item record
AbstractRAPPER (Radiogenomics: Assessment of Polymorphisms for Predicting the Effects of Radiotherapy) is a success story for national collaborative translational science. The study was established with the aim of identifying genetic variants associated with a patient’s risk of developing radiotherapy side-effects that could be combined in a clinical test incorporating non-genetic risk factors to individualise treatment . Underpinned by hypothesis-driven science, RAPPER collects blood to extract germline DNA from patients with high-quality clinical outcome data e collected mainly in national trials led by members of the UK clinical oncology community. It is an effort that we, as a community, should be very proud of. This editorial provides an update on the status of RAPPER and its future ambitions.
CitationBurnet NG, Barnett GC, Summersgill HR, Dunning AM, West CML. RAPPER - A success story for collaborative translational radiotherapy research. Clin Oncol. 2019;31(7):416-9.
- The evolution of chemoradiation for glioblastoma: a modern success story.
- Authors: Mirimanoff RO
- Issue date: 2006 Jan
- Biologics for psoriasis: a translational research success story.
- Authors: Lebwohl M
- Issue date: 2015 May
- Results of the first interim analysis of the RAPPER II trial in patients with spinal cord injury: ambulation and functional exercise programs in the REX powered walking aid.
- Authors: Birch N, Graham J, Priestley T, Heywood C, Sakel M, Gall A, Nunn A, Signal N
- Issue date: 2017 Jun 19
- RAPPER: A new method for rapid assessment of macroalgae as a complement to diatom-based assessments of ecological status.
- Authors: Kelly MG, Krokowski J, Harding JPC
- Issue date: 2016 Oct 15
- Broadening measures of success: results of a behavioral health translational research training program.
- Authors: Baldwin JA, Williamson HJ, Eaves ER, Levin BL, Burton DL, Massey OT
- Issue date: 2017 Jul 24