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    Biological benefits of ultra-high dose rate flash radiotherapy: sleeping beauty awoken

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    Authors
    Vozenin, M
    Hendry, Jolyon H
    Limoli, C
    Affiliation
    Laboratory of Radiation Oncology/CHUV, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
    Issue Date
    2019
    
    Metadata
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    Abstract
    FLASH radiotherapy (FLASH-RT) is a technology that could modify the way radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of radiotherapy at dose rates several orders of magnitude higher than those currently used in routine clinical practice. This very short time of exposure leads to the striking observation of relative protection of normal tissues that are exposed to FLASH-RT as compared with conventional dose rate radiotherapy. Here we summarise the current knowledge about the FLASH effect and provide a synthesis of the observations that have been reported on various experimental animal models (mice, zebrafish, pig, cats), various organs (lung, gut, brain, skin) and by various groups across 40 years of research. We also propose possible mechanisms for the FLASH effect, as well as possible paths for clinical application.
    Citation
    Vozenin MC, Hendry JH, Limoli CL. Biological benefits of ultra-high dose rate flash radiotherapy: sleeping beauty awoken . Clin Oncol (R Coll Radiol). 2019.
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/621849
    DOI
    10.1016/j.clon.2019.04.001
    PubMed ID
    31010708
    Additional Links
    https://dx.doi.org/10.1016/j.clon.2019.04.001
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2019.04.001
    Scopus Count
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