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dc.contributor.authorTariq, Noor-Ul-Ain
dc.contributor.authorMcNamara, Mairead G
dc.contributor.authorValle, Juan W
dc.date.accessioned2019-06-04T09:44:30Z
dc.date.available2019-06-04T09:44:30Z
dc.date.issued2019en
dc.identifier.citationTariq NU, McNamara MG, Valle JW. Biliary tract cancers: current knowledge, clinical candidates and future challenges. Cancer Manag Res. 2019; 11:2623-42.en
dc.identifier.pmid31015767en
dc.identifier.doi10.2147/CMAR.S157092en
dc.identifier.urihttp://hdl.handle.net/10541/621847
dc.description.abstractBiliary tract cancers (BTCs) are rare with poor prognosis. Due to the advent of genomic sequencing, new data have emerged regarding the molecular makeup of this disease. To add to the complexity, various subtypes also harbor a varied genetic composition. The commonly mutated genes associated with this cancer are KRAS, EGFR, IDH, FGFR and BAP1. Various clinical studies are looking at targeting these genetic mutations. Another therapeutic area of note is the potential for the use of immunotherapy in patients with BTC. Although BTC may be a result of chronic inflammation, this does not necessarily translate into increased immunogenicity. This literature review discusses the diverse molecular and immune-related pathways in patients with BTC and their potential therapeutic implications.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.2147/CMAR.S157092en
dc.titleBiliary tract cancers: current knowledge, clinical candidates and future challengesen
dc.typeArticleen
dc.contributor.departmentFaculty of Biomedicine and Health Sciences, Division of Cancer Sciences, University of Manchester, Manchester M13 9NT, UKen
dc.identifier.journalCancer Management and Researchen
refterms.dateFOA2019-06-06T13:43:57Z
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