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    Biliary tract cancers: current knowledge, clinical candidates and future challenges

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    Authors
    Tariq, Noor-Ul-Ain
    McNamara, Mairead G
    Valle, Juan W
    Affiliation
    Faculty of Biomedicine and Health Sciences, Division of Cancer Sciences, University of Manchester, Manchester M13 9NT, UK
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Biliary tract cancers (BTCs) are rare with poor prognosis. Due to the advent of genomic sequencing, new data have emerged regarding the molecular makeup of this disease. To add to the complexity, various subtypes also harbor a varied genetic composition. The commonly mutated genes associated with this cancer are KRAS, EGFR, IDH, FGFR and BAP1. Various clinical studies are looking at targeting these genetic mutations. Another therapeutic area of note is the potential for the use of immunotherapy in patients with BTC. Although BTC may be a result of chronic inflammation, this does not necessarily translate into increased immunogenicity. This literature review discusses the diverse molecular and immune-related pathways in patients with BTC and their potential therapeutic implications.
    Citation
    Tariq NU, McNamara MG, Valle JW. Biliary tract cancers: current knowledge, clinical candidates and future challenges. Cancer Manag Res. 2019; 11:2623-42.
    Journal
    Cancer Management and Research
    URI
    http://hdl.handle.net/10541/621847
    DOI
    10.2147/CMAR.S157092
    PubMed ID
    31015767
    Additional Links
    https://dx.doi.org/10.2147/CMAR.S157092
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.2147/CMAR.S157092
    Scopus Count
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