Screening tool for malignant bowel obstruction in relapsed, metastatic ovarian cancer
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Authors
Morgan, Robert DavidStamatopoulou, Sofia
Mescallado, Nerissa
Saunders, Geoff
Welch, Richard
Mitchell, Claire L
Hasan, Jurjees
Clamp, Andrew R
Jayson, Gordon C
Affiliation
Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UKIssue Date
2019
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Background: Malignant bowel obstruction (MBO) is a common cause of morbidity and mortality in women diagnosed with ovarian cancer. Earlier detection of MBO may improve patient outcomes. There are currently no screening tools to assist detection. Aim: We report a screening questionnaire that can be used to detect MBO, and how the severity score for key clinical symptoms correlate with radiological evidence of MBO from ovarian cancer. Design: A case-control study in which patients with relapsed, metastatic ovarian cancer were asked to answer 10 questions related to key clinical symptoms associated with intestinal obstruction. The study group included women with CT-confirmed MBO, whereas the control group had no evidence of MBO. Patients scored each question according to severity from 1 (least severe) to 5 (most severe). Setting/participants: Between 1 June and 31 December 2016, 37 women completed the screening questionnaire. Results: Patients in the study group (n=17) reported significantly higher (ie, more severe) scores for abdominal pain, nausea, vomiting and constipation. In contrast, differences in severity scores between groups did not differ significantly in response to questions regarding abdominal swelling, borborygmi, diarrhoea or loss of appetite. All patients in the study group more frequently stated that their symptoms had deteriorated within the 2 months prior to completing the questionnaire. Conclusion: Here we report the key clinical symptoms associated with radiologically-confirmed MBO in relapsed, metastatic ovarian cancer. We recommend healthcare practitioners focus on these specific symptoms during patient consultations in order to improve risk stratification of MBO.Citation
Morgan RD, Stamatopoulou S, Mescallado N, Saunders G, Welch R, Mitchell C, et al. Screening tool for malignant bowel obstruction in relapsed, metastatic ovarian cancer. ESMO Open. 2019; 4(2):e000463.Journal
ESMO OpenDOI
10.1136/esmoopen-2018-000463PubMed ID
30962962Additional Links
https://dx.doi.org/10.1136/esmoopen-2018-000463Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1136/esmoopen-2018-000463
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