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dc.contributor.authorJoseph, N
dc.contributor.authorMcWilliam, Alan
dc.contributor.authorKennedy, Jason
dc.contributor.authorHaslett, Kate
dc.contributor.authorMahil, J
dc.contributor.authorGavarraju, A
dc.contributor.authorMistry, Hitesh
dc.contributor.authorvan Herk, Marcel
dc.contributor.authorFaivre-Finn, Corinne
dc.contributor.authorChoudhury, Ananya
dc.date.accessioned2019-06-04T09:44:26Z
dc.date.available2019-06-04T09:44:26Z
dc.date.issued2019en
dc.identifier.citationJoseph N, McWilliam A, Kennedy J, Haslett K, Mahil J, Gavarraju A, et al. Post-treatment lymphocytopaenia, integral body dose and overall survival in lung cancer patients treated with radical radiotherapy. Radiother Oncol. 2019; 135:115-9.en
dc.identifier.pmid31015156en
dc.identifier.doi10.1016/j.radonc.2019.03.008en
dc.identifier.urihttp://hdl.handle.net/10541/621821
dc.description.abstractINTRODUCTION: Post-treatment lymphocytopaenia is a recognized complication of thoracic radiotherapy likely due to irradiation of a large volume of circulatory blood. We hypothesize that post-treatment absolute lymphocyte count (ALC) is associated with integral body dose and overall survival (OS) in lung cancer patients treated with radical radiotherapy. MATERIALS AND METHODS: Data on clinicopathological variables, dosimetric parameters, and pre and post-treatment blood counts were collected retrospectively in 217 lung cancer patients (131 with non-small cell lung cancer and 86 with small cell lung cancer) treated with radical radiotherapy. Induction chemotherapy followed by radiotherapy and concurrent chemoradiotherapy were delivered in 89 (42%) and 99 (47%) patients respectively. Multiple stepwise regression analysis was performed separately for ALC and absolute neutrophil count (ANC) to derive a model for prediction of post-treatment count and multivariate analysis was performed for OS using a Cox regression model. RESULTS: There was a significant decline in post-treatment counts for both ANC and ALC (p?<?0.001). Multiple stepwise linear regression analysis confirmed pre-treatment ALC, body integral dose and use of concurrent chemotherapy as significant predictors of post-treatment ALC (R2?=?0.33, F(4,212)?=?26.6 p?<?0.001). Pre-treatment ANC, integral heart dose and number of fractions were significant predictors of post-treatment ANC (R2?=?0.18, F(3,213)?=?16.38 p?<?0.001). Low post-treatment ALC, high pre-treatment ANC, high planning target volume integral dose and lower number of fractions were predictive of inferior OS. CONCLUSIONS: There is a negative correlation between integral body dose and post-treatment ALC which is an adverse prognostic factor in lung cancer patients treated with radical radiotherapy.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1016/j.radonc.2019.03.008en
dc.titlePost-treatment lymphocytopaenia, integral body dose and overall survival in lung cancer patients treated with radical radiotherapyen
dc.typeArticleen
dc.contributor.departmentTellipalai Train Cancer Centre, Teaching Hospital Jaffna, Ministry of Health, Sri Lanka.en
dc.identifier.journalRadiotherapy and Oncologyen


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