Considering tumour volume for motion corrected DWI of colorectal liver metastases increases sensitivity of ADC to detect treatment-induced changes
AffiliationUniversity of Manchester, Wolfson Molecular Imaging Centre, Manchester, UK
MetadataShow full item record
AbstractADC is a potential post treatment imaging biomarker in colorectal liver metastasis however measurements are affected by respiratory motion. This is compounded by increased statistical uncertainty in ADC measurement with decreasing tumour volume. In this prospective study we applied a retrospective motion correction method to improve the image quality of 15 tumour data sets from 11 patients. We compared repeatability of ADC measurements corrected for motion artefact against non-motion corrected acquisition of the same data set. We then applied an error model that estimated the uncertainty in ADC repeatability measurements therefore taking into consideration tumour volume. Test-retest differences in ADC for each tumour, was scaled to their estimated measurement uncertainty, and 95% confidence limits were calculated, with a null hypothesis that there is no difference between the model distribution and the data. An early post treatment scan (within 7 days of starting treatment) was acquired for 12 tumours from 8 patients. When accounting for both motion artefact and statistical uncertainty due to tumour volumes, the threshold for detecting significant post treatment changes for an individual tumour in this data set, reduced from 30.3% to 1.7% (95% limits of agreement). Applying these constraints, a significant change in ADC (5th and 20th percentiles of the ADC histogram) was observed in 5 patients post treatment. For smaller studies, motion correcting data for small tumour volumes increased statistical efficiency to detect post treatment changes in ADC. Lower percentiles may be more sensitive than mean ADC for colorectal metastases.
CitationPathak R, Tian J, Thacker NA, Morris DM, Ragheb H, Saunders C, et al. Considering tumour volume for motion corrected DWI of colorectal liver metastases increases sensitivity of ADC to detect treatment-induced changes. Sci Rep. 2019 Mar 7;9(1):3828.
- A data-driven statistical model that estimates measurement uncertainty improves interpretation of ADC reproducibility: a multi-site study of liver metastases.
- Authors: Pathak R, Ragheb H, Thacker NA, Morris DM, Amiri H, Kuijer J, deSouza NM, Heerschap A, Jackson A
- Issue date: 2017 Oct 26
- Potential of MR histogram analyses for prediction of response to chemotherapy in patients with colorectal hepatic metastases.
- Authors: Liang HY, Huang YQ, Yang ZX, Ying-Ding, Zeng MS, Rao SX
- Issue date: 2016 Jul
- 3T diffusion-weighted MRI in the response assessment of colorectal liver metastases after chemotherapy: Correlation between ADC value and histological tumour regression grading.
- Authors: Donati F, Boraschi P, Pacciardi F, Cervelli R, Castagna M, Urbani L, Falaschi F, Caramella D
- Issue date: 2017 Jun
- Assessment of the residual tumour of colorectal liver metastases after chemotherapy: diffusion-weighted MR magnetic resonance imaging in the peripheral and entire tumour.
- Authors: Wagner M, Ronot M, Doblas S, Giraudeau C, Van Beers B, Belghiti J, Paradis V, Vilgrain V
- Issue date: 2016 Jan
- Predicting Treatment Response of Colorectal Cancer Liver Metastases to Conventional Lipiodol-Based Transarterial Chemoembolization Using Diffusion-Weighted MR Imaging: Value of Pretreatment Apparent Diffusion Coefficients (ADC) and ADC Changes Under Therapy.
- Authors: Lahrsow M, Albrecht MH, Bickford MW, Vogl TJ
- Issue date: 2017 Jun