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    Differentiated thyroid cancer in children: a UK multicentre review and review of the literature

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    Authors
    Lee, K
    Sharabiani, M
    Tumino, D
    Wadsley, J
    Gill, V
    Gerrard, G
    Sindhu, Retnabai
    Gaze, M
    Moss, L
    Newbold, K
    Affiliation
    Royal Marsden NHS Foundation Trust Thyroid Unit, London, UK
    Issue Date
    2019
    
    Metadata
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    Abstract
    AIMS: To obtain an overview of the management and outcomes of children aged 18 years or younger diagnosed with differentiated thyroid carcinoma of follicular cell origin across the UK, by collecting and analysing data from the limited number of centres treating these patients. This multicentre data might provide a more realistic perspective than single-institution series. MATERIALS AND METHODS: Six centres submitted data extracted from historical records on patients aged 18 years or younger, diagnosed between 1964 and 2017. The univariate and multivariable Cox proportional hazard model was used to identify potential predictors of progression-free survival, using national data as a control. RESULTS: Data on 166 patients were available for analysis. Females (74%) were predominant, and the age ranged from 3 to 19 years at diagnosis, mean 14.1 years. Nodal metastases were present in 51%; 12% had distant metastases. After surgery, 95% received radioactive iodine (39% on more than one occasion) and 4% received external beam radiotherapy. With a median follow-up duration of 5 years, 69% are alive with no evidence of disease; 20% are alive with a raised thyroglobulin level as the only evidence of residual disease; 6% have residual structural disease detectable on imaging; 2% have died, from cerebral metastases. CONCLUSION: Despite most patients having advanced disease at presentation, outcomes are very good. A national prospective registry should allow systematic collection of good-quality data and may facilitate research to further improve outcomes
    Citation
    Lee KA, Sharabiani MTA, Tumino D, Wadsley J, Gill V, Gerrard G, et al.Differentiated thyroid cancer in children: a UK multicentre review and review of the literature. Clin Oncol (R Coll Radiol). 2019.
    Journal
    Clinical Oncology (Royal College of Radiologists (Great Britain))
    URI
    http://hdl.handle.net/10541/621776
    DOI
    10.1016/j.clon.2019.02.005
    PubMed ID
    30878210
    Additional Links
    https://dx.doi.org/10.1016/j.clon.2019.02.005
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2019.02.005
    Scopus Count
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