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dc.contributor.authorEskian, M
dc.contributor.authorKhorasanizadeh, M
dc.contributor.authorZinzani, P
dc.contributor.authorIllidge, Timothy M
dc.contributor.authorRezaei, N
dc.date.accessioned2019-04-29T09:48:57Z
dc.date.available2019-04-29T09:48:57Z
dc.date.issued2019en
dc.identifier.citationEskian M, Khorasanizadeh M, Zinzani PL, Illidge TM, Rezaei N. Novel methods to improve the efficiency of radioimmunotherapy for Non-Hodgkin lymphoma. Int Rev Immunol. 2019 Mar 31:1-13.en
dc.identifier.pmid30931651en
dc.identifier.doi10.1080/08830185.2019.1588266en
dc.identifier.urihttp://hdl.handle.net/10541/621763
dc.description.abstractRadioimmunotherapy (RIT) is a novel strategy for treating non-Hodgkin lymphoma (NHL). Several studies have shown the promising results of using RIT in NHL, which have led to FDA approval for two RIT agents in treating low grade NHL. In spite of these favorable results in low-grade NHL, most of the aggressive or relapsed/refractory NHL subjects experience relapses following RIT. Although more aggressive treatments such as myeloablative doses of RIT followed by stem cell transplantation appear to be able to provide a longer survival for some patients these approaches are associated with significant treatment-related adverse events and challenging to deliver in most centers. Therefore, it seems reasonable to develop treatment approaches that enhance the efficiency of RIT, while reducing its toxicity. In this paper, novel methods that improve the efficiency of RIT and reduce its toxicity through various mechanisms are reviewed. Further clinical development of these methods could expand the NHL patient groups eligible for receiving RIT, and even extend the use of RIT to new indications and disease groups in future.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1080/08830185.2019.1588266en
dc.titleNovel methods to improve the efficiency of radioimmunotherapy for Non-Hodgkin lymphomaen
dc.typeArticleen
dc.contributor.departmentResearch Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences , Tehran , Iranen
dc.identifier.journalInternational Reviews of Immunologyen
dc.description.noteen]


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