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    Novel methods to improve the efficiency of radioimmunotherapy for Non-Hodgkin lymphoma

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    Authors
    Eskian, M
    Khorasanizadeh, M
    Zinzani, P
    Illidge, Timothy M
    Rezaei, N
    Affiliation
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences , Tehran , Iran
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    Radioimmunotherapy (RIT) is a novel strategy for treating non-Hodgkin lymphoma (NHL). Several studies have shown the promising results of using RIT in NHL, which have led to FDA approval for two RIT agents in treating low grade NHL. In spite of these favorable results in low-grade NHL, most of the aggressive or relapsed/refractory NHL subjects experience relapses following RIT. Although more aggressive treatments such as myeloablative doses of RIT followed by stem cell transplantation appear to be able to provide a longer survival for some patients these approaches are associated with significant treatment-related adverse events and challenging to deliver in most centers. Therefore, it seems reasonable to develop treatment approaches that enhance the efficiency of RIT, while reducing its toxicity. In this paper, novel methods that improve the efficiency of RIT and reduce its toxicity through various mechanisms are reviewed. Further clinical development of these methods could expand the NHL patient groups eligible for receiving RIT, and even extend the use of RIT to new indications and disease groups in future.
    Citation
    Eskian M, Khorasanizadeh M, Zinzani PL, Illidge TM, Rezaei N. Novel methods to improve the efficiency of radioimmunotherapy for Non-Hodgkin lymphoma. Int Rev Immunol. 2019 Mar 31:1-13.
    Journal
    International Reviews of Immunology
    URI
    http://hdl.handle.net/10541/621763
    DOI
    10.1080/08830185.2019.1588266
    PubMed ID
    30931651
    Additional Links
    https://dx.doi.org/10.1080/08830185.2019.1588266
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1080/08830185.2019.1588266
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