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dc.contributor.authorRudin, CM
dc.contributor.authorPoirier, JT
dc.contributor.authorByers, LA
dc.contributor.authorDive, Caroline
dc.contributor.authorDowlati, A
dc.contributor.authorGeorge, J
dc.contributor.authorHeymach, JV
dc.contributor.authorJohnson, JE
dc.contributor.authorLehman, JM
dc.contributor.authorMacPherson, D
dc.contributor.authorMassion, PP
dc.contributor.authorMinna, JD
dc.contributor.authorOliver, TG
dc.contributor.authorQuaranta, V
dc.contributor.authorSage, J
dc.contributor.authorThomas, RK
dc.contributor.authorVakoc, CR
dc.contributor.authorGazdar, AF
dc.date.accessioned2019-04-29T09:48:54Z
dc.date.available2019-04-29T09:48:54Z
dc.date.issued2019en
dc.identifier.citationRudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, et al. Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer. 2019 Mar 29.en
dc.identifier.pmid30926931en
dc.identifier.doi10.1038/s41568-019-0133-9en
dc.identifier.urihttp://hdl.handle.net/10541/621745
dc.description.abstractSmall cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. Several lines of evidence, from SCLC primary human tumours, patient-derived xenografts, cancer cell lines and genetically engineered mouse models, appear to be converging on a new model of SCLC subtypes defined by differential expression of four key transcription regulators: achaete-scute homologue 1 (ASCL1; also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). In this Perspectives article, we review and synthesize these recent lines of evidence and propose a working nomenclature for SCLC subtypes defined by relative expression of these four factors. Defining the unique therapeutic vulnerabilities of these subtypes of SCLC should help to focus and accelerate therapeutic research, leading to rationally targeted approaches that may ultimately improve clinical outcomes for patients with this disease.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41568-019-0133-9en
dc.titleMolecular subtypes of small cell lung cancer: a synthesis of human and mouse model dataen
dc.typeArticleen
dc.contributor.departmentMemorial Sloan Kettering Cancer Center, New York, NY, USAen
dc.identifier.journalNature Reviews Canceren
dc.description.noteen]


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