Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity
AffiliationDepartment of Excellence of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy
MetadataShow full item record
AbstractAIM: Low-grade chronic inflammation characterizes obesity and metabolic syndrome. Here we aim at investigating the impact of the acute-phase protein long pentraxin 3 (PTX3) on the immune-inflammatory response occurring during diet-induced obesity. METHODS AND RESULTS: PTX3 deficiency in mice fed a high fat diet for 20 weeks protects from weight gain and adipose tissue deposition in visceral and subcutaneous depots. This effect is not related to changes in glucose homeostasis and lipid metabolism but is associated with the improved immune cell phenotype in the adipose tissue of Ptx3 deficient animals which is characterized by M2-macrophages polarization and increased angiogenesis. These findings are recapitulated in humans where carriers of a PTX3 haplotype (PTX3 h2/h2 haplotype), resulting in lower PTX3 plasma levels, presented with a reduced prevalence of obesity and decreased abdominal adiposity compared to non-carriers. CONCLUSIONS: Our results support a critical role for PTX3 in the onset of obesity by promoting inflammation and limiting adipose tissue vascularization and delineate PTX3 targeting as a valuable strategy for the treatment of adipose tissue-associated inflammatory response.
CitationBonacina F, Moregola A, Porte R, Baragetti A, Bonavita E, Salatin A, et al. Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity. Cardiovasc Res. 2019 Mar 12.
- Pentraxin 3 deficiency exacerbates lipopolysaccharide-induced inflammation in adipose tissue.
- Authors: Guo H, Qiu X, Deis J, Lin TY, Chen X
- Issue date: 2020 Feb
- Plasma PTX3 protein levels inversely correlate with insulin secretion and obesity, whereas visceral adipose tissue PTX3 gene expression is increased in obesity.
- Authors: Osorio-Conles O, Guitart M, Chacón MR, Maymo-Masip E, Moreno-Navarrete JM, Montori-Grau M, Näf S, Fernandez-Real JM, Vendrell J, Gómez-Foix AM
- Issue date: 2011 Dec
- Mice that are fed a high-fat diet display increased hepcidin expression in adipose tissue.
- Authors: Gotardo ÉM, dos Santos AN, Miyashiro RA, Gambero S, Rocha T, Ribeiro ML, Gambero A
- Issue date: 2013
- MIF deficiency does not alter glucose homeostasis or adipose tissue inflammatory cell infiltrates during diet-induced obesity.
- Authors: Conine SJ, Cross JV
- Issue date: 2014 Feb
- NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet.
- Authors: Pepping JK, Freeman LR, Gupta S, Keller JN, Bruce-Keller AJ
- Issue date: 2013 Feb 15