Regular sunscreen use and risk of mortality: long-term follow-up of a dkin cancer prevention trial
AffiliationCancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Brisbane, Australia
MetadataShow full item record
AbstractINTRODUCTION: Sunscreen is widely used to protect the skin from harmful effects of sun exposure. However, there are concerns that sunscreens may negatively affect overall health. Evidence of the general safety of long-term regular sunscreen use is therefore needed. METHODS: The effect of long-term sunscreen use on mortality was assessed over a 21-year period (1993-2014) among 1,621 Australian adults who had participated in a randomized skin cancer prevention trial of regular versus discretionary sunscreen use (1992-1996). In 2018, an intention-to-treat analysis was conducted using Cox proportional hazards regression to compare death rates in people who were randomized to apply sunscreen daily for 4.5years, versus randomized to use sunscreen at their usual, discretionary level. All-cause mortality and deaths resulting from cardiovascular disease, cancer, and other causes were considered. RESULTS: In total, 160 deaths occurred in the daily sunscreen group compared with 170 deaths in the discretionary sunscreen group (hazard ratio=0.94, 95% CI=0.76, 1.17); 59vs 76 cardiovascular disease deaths (hazard ratio=0.77, 95% CI=0.55, 1.08), 63vs 58 cancer deaths (hazard ratio=1.09, 95% CI=0.76, 1.57), and 45vs 44 deaths resulting from other causes (hazard ratio=1.02, 95% CI=0.67, 1.54) occurred respectively. CONCLUSIONS: Regular use of a sun protection factor 16 sunscreen on head, neck, arms, and hands for 4.5years did not increase mortality.
CitationLindstrom AR, von Schuckmann LA, Hughes MCB, Williams GM, Green AC, van der Pols JC. Regular Sunscreen Use and Risk of Mortality: Long-Term Follow-up of a Skin Cancer Prevention Trial. Am J Prev Med. 2019 Mar 15.
JournalAmerican Journal of Preventive Medicine
- Long-term increase in sunscreen use in an Australian community after a skin cancer prevention trial.
- Authors: van der Pols JC, Williams GM, Neale RE, Clavarino A, Green AC
- Issue date: 2006 Mar
- Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial.
- Authors: Green A, Williams G, Neale R, Hart V, Leslie D, Parsons P, Marks GC, Gaffney P, Battistutta D, Frost C, Lang C, Russell A
- Issue date: 1999 Aug 28
- Sun protection for preventing basal cell and squamous cell skin cancers.
- Authors: Sánchez G, Nova J, Rodriguez-Hernandez AE, Medina RD, Solorzano-Restrepo C, Gonzalez J, Olmos M, Godfrey K, Arevalo-Rodriguez I
- Issue date: 2016 Jul 25
- Current principles of sunscreen use in children.
- Authors: Quatrano NA, Dinulos JG
- Issue date: 2013 Feb
- Sun Protection by Beach Umbrella vs Sunscreen With a High Sun Protection Factor: A Randomized Clinical Trial.
- Authors: Ou-Yang H, Jiang LI, Meyer K, Wang SQ, Farberg AS, Rigel DS
- Issue date: 2017 Mar 1