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    Regular sunscreen use and risk of mortality: long-term follow-up of a dkin cancer prevention trial

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    Authors
    Lindstrom, AR
    von Schuckmann, LA
    Hughes, MCB
    Williams, GM
    Green, Adèle C
    van der Pols, JC
    Affiliation
    Cancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Brisbane, Australia
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    INTRODUCTION: Sunscreen is widely used to protect the skin from harmful effects of sun exposure. However, there are concerns that sunscreens may negatively affect overall health. Evidence of the general safety of long-term regular sunscreen use is therefore needed. METHODS: The effect of long-term sunscreen use on mortality was assessed over a 21-year period (1993-2014) among 1,621 Australian adults who had participated in a randomized skin cancer prevention trial of regular versus discretionary sunscreen use (1992-1996). In 2018, an intention-to-treat analysis was conducted using Cox proportional hazards regression to compare death rates in people who were randomized to apply sunscreen daily for 4.5years, versus randomized to use sunscreen at their usual, discretionary level. All-cause mortality and deaths resulting from cardiovascular disease, cancer, and other causes were considered. RESULTS: In total, 160 deaths occurred in the daily sunscreen group compared with 170 deaths in the discretionary sunscreen group (hazard ratio=0.94, 95% CI=0.76, 1.17); 59vs 76 cardiovascular disease deaths (hazard ratio=0.77, 95% CI=0.55, 1.08), 63vs 58 cancer deaths (hazard ratio=1.09, 95% CI=0.76, 1.57), and 45vs 44 deaths resulting from other causes (hazard ratio=1.02, 95% CI=0.67, 1.54) occurred respectively. CONCLUSIONS: Regular use of a sun protection factor 16 sunscreen on head, neck, arms, and hands for 4.5years did not increase mortality.
    Citation
    Lindstrom AR, von Schuckmann LA, Hughes MCB, Williams GM, Green AC, van der Pols JC. Regular Sunscreen Use and Risk of Mortality: Long-Term Follow-up of a Skin Cancer Prevention Trial. Am J Prev Med. 2019 Mar 15.
    Journal
    American Journal of Preventive Medicine
    URI
    http://hdl.handle.net/10541/621740
    DOI
    10.1016/j.amepre.2018.11.025
    PubMed ID
    30885518
    Additional Links
    https://dx.doi.org/10.1016/j.amepre.2018.11.025
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.amepre.2018.11.025
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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