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    JNK signaling in cancer cell survival

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    Authors
    Wu, Q
    Wu, W
    Fu, B
    Shi, Lei
    Wang, X
    Kuca, K
    Affiliation
    College of Life Science, Yangtze University, Jingzhou, China
    Issue Date
    2019
    
    Metadata
    Show full item record
    Abstract
    c-Jun N-terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with NF-?B, JAK/STAT, and other signaling molecules to exert a survival function. JNK positively regulates autophagy to counteract apoptosis, and its effect on autophagy is related to the development of chemotherapeutic resistance. The prosurvival effect of JNK may involve an immune evasion mechanism mediated by transforming growth factor-?, toll-like receptors, interferon-?, and autophagy, as well as compensatory JNK-dependent cell proliferation. The present review focuses on recent advances in understanding the prosurvival function of JNK and its role in tumor development and chemoresistance, including a comprehensive analysis of the molecular mechanisms underlying JNK-mediated cancer cell survival. There is a focus on the specific "Yin and Yang" functions of JNK1 and JNK2 in the regulation of cancer cell survival. We highlight recent advances in our knowledge of the roles of JNK in cancer cell survival, which may provide insight into the distinct functions of JNK in cancer and its potential for cancer therapy.
    Citation
    Wu Q, Wu W, Fu B, Shi L, Wang X, Kuca K. JNK signaling in cancer cell survival. Med Res Rev. 2019 Mar 25.
    Journal
    Medicinal Research Reviews
    URI
    http://hdl.handle.net/10541/621738
    DOI
    10.1002/med.21574
    PubMed ID
    30912203
    Additional Links
    https://dx.doi.org/10.1002/med.21574
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1002/med.21574
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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