Affiliation
College of Life Science, Yangtze University, Jingzhou, ChinaIssue Date
2019
Metadata
Show full item recordAbstract
c-Jun N-terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with NF-?B, JAK/STAT, and other signaling molecules to exert a survival function. JNK positively regulates autophagy to counteract apoptosis, and its effect on autophagy is related to the development of chemotherapeutic resistance. The prosurvival effect of JNK may involve an immune evasion mechanism mediated by transforming growth factor-?, toll-like receptors, interferon-?, and autophagy, as well as compensatory JNK-dependent cell proliferation. The present review focuses on recent advances in understanding the prosurvival function of JNK and its role in tumor development and chemoresistance, including a comprehensive analysis of the molecular mechanisms underlying JNK-mediated cancer cell survival. There is a focus on the specific "Yin and Yang" functions of JNK1 and JNK2 in the regulation of cancer cell survival. We highlight recent advances in our knowledge of the roles of JNK in cancer cell survival, which may provide insight into the distinct functions of JNK in cancer and its potential for cancer therapy.Citation
Wu Q, Wu W, Fu B, Shi L, Wang X, Kuca K. JNK signaling in cancer cell survival. Med Res Rev. 2019 Mar 25.Journal
Medicinal Research ReviewsDOI
10.1002/med.21574PubMed ID
30912203Additional Links
https://dx.doi.org/10.1002/med.21574Type
ArticleLanguage
enae974a485f413a2113503eed53cd6c53
10.1002/med.21574
Scopus Count
Collections
Related articles
- Vitexin 6, a novel lignan, induces autophagy and apoptosis by activating the Jun N-terminal kinase pathway.
- Authors: Zhou J, Hu H, Long J, Wan F, Li L, Zhang S, Shi YE, Chen Y
- Issue date: 2013 Oct
- C-Jun N-terminal kinase signalling pathway in response to cisplatin.
- Authors: Yan D, An G, Kuo MT
- Issue date: 2016 Nov
- Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells.
- Authors: Tang ZH, Zhang LL, Li T, Lu JH, Ma DL, Leung CH, Chen XP, Jiang HL, Wang YT, Lu JJ
- Issue date: 2015 Dec 22
- JNK/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts.
- Authors: Ikeda F, Matsubara T, Tsurukai T, Hata K, Nishimura R, Yoneda T
- Issue date: 2008 Jun
- MicroRNA-181a Regulates Apoptosis and Autophagy Process in Parkinson's Disease by Inhibiting p38 Mitogen-Activated Protein Kinase (MAPK)/c-Jun N-Terminal Kinases (JNK) Signaling Pathways.
- Authors: Liu Y, Song Y, Zhu X
- Issue date: 2017 Apr 2