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dc.contributor.authorEscala-Garcia, M
dc.contributor.authorGuo, Q
dc.contributor.authorDork, T
dc.contributor.authorCanisius, S
dc.contributor.authorKeeman, R
dc.contributor.authorDennis, J
dc.contributor.authorBeesley, J
dc.contributor.authorLecarpentier, J
dc.contributor.authorBolla, K
dc.contributor.authorWang, Q
dc.contributor.authorAbraham, J
dc.contributor.authorAndrulis, L
dc.contributor.authorAnton-Culver, H
dc.contributor.authorArndt, V
dc.contributor.authorAuer, L
dc.contributor.authorBeckmann, W
dc.contributor.authorBehrens, S
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBernstein, L
dc.contributor.authorBlomqvist, C
dc.contributor.authorBoeckx, B
dc.contributor.authorBojesen, E
dc.contributor.authorBonanni, B
dc.contributor.authorBorresen-Dale, L
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBrentnall, A
dc.contributor.authorBrinton, L
dc.contributor.authorBroberg, P
dc.contributor.authorBrock, W
dc.contributor.authorBrucker, Y
dc.contributor.authorBurwinkel, B
dc.contributor.authorCaldas, C
dc.contributor.authorCaldes, T
dc.contributor.authorCampa, D
dc.contributor.authorCanzian, F
dc.contributor.authorCarracedo, A
dc.contributor.authorCarter, D
dc.contributor.authorCastelao, E
dc.contributor.authorChang-Claude, J
dc.contributor.authorChanock, J
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorCheng, D
dc.contributor.authorChin, F
dc.contributor.authorClarke, L
dc.contributor.authorCordina-Duverger, E
dc.contributor.authorCouch, J
dc.contributor.authorCox, G
dc.contributor.authorCox, A
dc.contributor.authorCross, S
dc.contributor.authorCzene, K
dc.contributor.authorDaly, B
dc.contributor.authorDevilee, P
dc.contributor.authorDunn, A
dc.contributor.authorDunning, M
dc.contributor.authorDurcan, L
dc.contributor.authorDwek, M
dc.contributor.authorEarl, M
dc.contributor.authorEkici, B
dc.contributor.authorEliassen, H
dc.contributor.authorEllberg, C
dc.contributor.authorEngel, C
dc.contributor.authorEriksson, M
dc.contributor.authorEvans, G
dc.contributor.authorFigueroa, J
dc.contributor.authorFlesch-Janys, D
dc.contributor.authorFlyger, H
dc.contributor.authorGabrielson, M
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGalle, E
dc.contributor.authorGapstur, M
dc.contributor.authorGarcia-Closas, M
dc.contributor.authorGarcia-Saenz, A
dc.contributor.authorGaudet, M
dc.contributor.authorGeorge, A
dc.contributor.authorGeorgoulias, V
dc.contributor.authorGiles, G
dc.contributor.authorGlendon, G
dc.contributor.authorGoldgar, E
dc.contributor.authorGonzalez-Neira, A
dc.contributor.authorAlnaes, G
dc.contributor.authorGrip, M
dc.contributor.authorGuenel, P
dc.contributor.authorHaeberle, L
dc.contributor.authorHahnen, E
dc.contributor.authorHaiman, A
dc.contributor.authorHakansson, N
dc.contributor.authorHall, P
dc.contributor.authorHamann, U
dc.contributor.authorHankinson, S
dc.contributor.authorHarkness, F
dc.contributor.authorHarrington, A
dc.contributor.authorHart, N
dc.contributor.authorHartikainen, JM
dc.contributor.authorHein, A
dc.contributor.authorHillemanns, P
dc.contributor.authorHiller, L
dc.contributor.authorHolleczek, B
dc.contributor.authorHollestelle, A
dc.contributor.authorHooning, J
dc.contributor.authorHoover, N
dc.contributor.authorHopper, L
dc.contributor.authorHowell, Anthony
dc.contributor.authorHuang, G
dc.contributor.authorHumphreys, K
dc.contributor.authorHunter, J
dc.contributor.authorJanni, W
dc.contributor.authorJohn, M
dc.contributor.authorJones, E
dc.contributor.authorJukkola-Vuorinen, A
dc.contributor.authorJung, A
dc.contributor.authorKaaks, R
dc.contributor.authorKabisch, M
dc.contributor.authorKaczmarek, K
dc.contributor.authorKerin, J
dc.contributor.authorKhan, S
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKiiski, I
dc.contributor.authorKitahara, M
dc.contributor.authorKnight, A
dc.contributor.authorKo, D
dc.contributor.authorKoppert, B
dc.contributor.authorKosma, M
dc.contributor.authorKraft, P
dc.contributor.authorKristensen, N
dc.contributor.authorKruger, U
dc.contributor.authorKuhl, T
dc.contributor.authorLambrechts, D
dc.contributor.authorLe, L
dc.contributor.authorLee, E
dc.contributor.authorLejbkowicz, F
dc.contributor.authorLi, L
dc.contributor.authorLindblom, A
dc.contributor.authorLindstrom, S
dc.contributor.authorLinet, M
dc.contributor.authorLissowska, J
dc.contributor.authorLo, Y
dc.contributor.authorLoibl, S
dc.contributor.authorLubinski, J
dc.contributor.authorLux, P
dc.contributor.authorMacInnis, J
dc.contributor.authorMaierthaler, M
dc.contributor.authorMaishman, T
dc.contributor.authorMakalic, E
dc.contributor.authorMannermaa, A
dc.contributor.authorManoochehri, M
dc.contributor.authorManoukian, S
dc.contributor.authorMargolin, S
dc.contributor.authorMartinez, E
dc.contributor.authorMavroudis, D
dc.contributor.authorMcLean, C
dc.contributor.authorMeindl, A
dc.contributor.authorMiddha, P
dc.contributor.authorMiller, N
dc.contributor.authorMilne, L
dc.contributor.authorMoreno, F
dc.contributor.authorMulligan, M
dc.contributor.authorMulot, C
dc.contributor.authorNassir, R
dc.contributor.authorNeuhausen, L
dc.contributor.authorNewman, T
dc.contributor.authorNielsen, F
dc.contributor.authorNordestgaard, G
dc.contributor.authorNorman, A
dc.contributor.authorOlsson, H
dc.contributor.authorOrr, N
dc.contributor.authorPankratz, S
dc.contributor.authorPark-Simon, TW
dc.contributor.authorPerez, A
dc.contributor.authorPerez-Barrios, C
dc.contributor.authorPeterlongo, P
dc.contributor.authorPetridis, C
dc.contributor.authorPinchev, M
dc.contributor.authorPrajzendanc, K
dc.contributor.authorPrentice, R
dc.contributor.authorPresneau, N
dc.contributor.authorProkofieva, D
dc.contributor.authorPylkas, K
dc.contributor.authorRack, B
dc.contributor.authorRadice, P
dc.contributor.authorRamachandran, D
dc.contributor.authorRennert, G
dc.contributor.authorRennert, S
dc.contributor.authorRhenius, V
dc.contributor.authorRomero, A
dc.contributor.authorRoylance, R
dc.contributor.authorSaloustros, E
dc.contributor.authorSawyer, J
dc.contributor.authorSchmidt, DF
dc.contributor.authorSchmutzler, K
dc.contributor.authorSchneeweiss, A
dc.contributor.authorSchoemaker, J
dc.contributor.authorSchumacher, F
dc.contributor.authorSchwentner, L
dc.contributor.authorScott, J
dc.contributor.authorScott, C
dc.contributor.authorSeynaeve, C
dc.contributor.authorShah, M
dc.contributor.authorSimard, J
dc.contributor.authorSmeets, A
dc.contributor.authorSohn, C
dc.contributor.authorSouthey, C
dc.contributor.authorSwerdlow, J
dc.contributor.authorTalhouk, A
dc.contributor.authorTamimi, M
dc.contributor.authorTapper, J
dc.contributor.authorTeixeira, R
dc.contributor.authorTengstrom, M
dc.contributor.authorTerry, B
dc.contributor.authorThone, K
dc.contributor.authorTollenaar, M
dc.contributor.authorTomlinson, I
dc.contributor.authorTorres, D
dc.contributor.authorTruong, T
dc.contributor.authorTurman, C
dc.contributor.authorTurnbull, C
dc.contributor.authorUlmer, U
dc.contributor.authorUntch, M
dc.contributor.authorVachon, C
dc.contributor.authorvan Asperen, J
dc.contributor.authorvan den Ouweland, W
dc.contributor.authorvan Veen, M
dc.contributor.authorWendt, C
dc.contributor.authorWhittemore, S
dc.contributor.authorWillett, W
dc.contributor.authorWinqvist, R
dc.contributor.authorWolk, A
dc.contributor.authorYang, R
dc.contributor.authorZhang, Y
dc.contributor.authorEaston, F
dc.contributor.authorFasching, A
dc.contributor.authorNevanlinna, H
dc.contributor.authorEccles, M
dc.contributor.authorPharoah, P
dc.contributor.authorSchmidt, K
dc.date.accessioned2019-03-29T14:22:35Z
dc.date.available2019-03-29T14:22:35Z
dc.date.issued2019en
dc.identifier.citationEscala-Garcia M, Guo Q, Dork T, Canisius S, Keeman R, Dennis J, et al. Genome-wide association study of germline variants and breast cancer-specific mortality. Br J Cancer. 2019 Feb 21.en
dc.identifier.pmid30787463en
dc.identifier.doi10.1038/s41416-019-0393-xen
dc.identifier.urihttp://hdl.handle.net/10541/621706
dc.description.abstractBACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P?<?5?×?10-8. For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP?=?7%, P?=?1.28?×?10-7, hazard ratio [HR]?=?0.88, 95% confidence interval [CI]?=?0.84-0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7:rs67918676 (BFDP?=?11%, P?=?1.38?×?10-7, HR?=?1.27, 95% CI?=?1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP?<?15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients.en
dc.language.isoenen
dc.relation.urlhttps://dx.doi.org/10.1038/s41416-019-0393-xen
dc.titleGenome-wide association study of germline variants and breast cancer-specific mortalityen
dc.typeArticleen
dc.contributor.departmentRadiotherapy Department, Christie Hospital NHS Trust, Manchester, UKen
dc.identifier.journalBritish Journal of Canceren
dc.description.noteen]
refterms.dateFOA2020-04-22T12:36:05Z


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