Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: challenges of daily clinical practice
McNamara, Mairead G
Hubner, Richard A
Valle, Juan W
AffiliationCleveland Clinic Taussig Cancer Institute, Cleveland
MetadataShow full item record
AbstractBACKGROUND: Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family. AIM: To assess the referral pathways for genetic consultations in PDAC. METHODS: Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria. RESULTS: Four-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population. CONCLUSION: Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments. KEYWORDS: BRCA; Genetic consultation; Genetic counselling; Germline; Pancreatic adenocarcinoma
CitationFulton A, Lamarca A, Nuttall C, McCallum L, Pihlak R, O'Reilly D, et al. Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: challenges of daily clinical practice. World J Gastrointest Oncol. 2019 Feb 15;11(2):102-16.
JournalWorld Journal of Gastrointestinal Oncology
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