COSMOS-E: guidance on conducting systematic reviews and meta-analyses of observational studies of etiology
AffiliationThe Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands
MetadataShow full item record
AbstractBACKGROUND: To our knowledge, no publication providing overarching guidance on the conduct of systematic reviews of observational studies of etiology exists. METHODS AND FINDINGS: Conducting Systematic Reviews and Meta-Analyses of Observational Studies of Etiology (COSMOS-E) provides guidance on all steps in systematic reviews of observational studies of etiology, from shaping the research question, defining exposure and outcomes, to assessing the risk of bias and statistical analysis. The writing group included researchers experienced in meta-analyses and observational studies of etiology. Standard peer-review was performed. While the structure of systematic reviews of observational studies on etiology may be similar to that for systematic reviews of randomised controlled trials, there are specific tasks within each component that differ. Examples include assessment for confounding, selection bias, and information bias. In systematic reviews of observational studies of etiology, combining studies in meta-analysis may lead to more precise estimates, but such greater precision does not automatically remedy potential bias. Thorough exploration of sources of heterogeneity is key when assessing the validity of estimates and causality. CONCLUSION: As many reviews of observational studies on etiology are being performed, this document may provide researchers with guidance on how to conduct and analyse such reviews.
CitationDekkers O, Vandenbroucke J, Cevallos M, Renehan AG, Altman D, Egger M. COSMOS-E: guidance on conducting systematic reviews and meta-analyses of observational studies of etiology. PLoS Med. 2019;16(2):e1002742.
- [Introduction to COSMOS-E: Guidance on conducting systematic reviews and Meta-analyses on etiology of observational studies].
- Authors: Wang WW, Yang ZR, Zhou QX, Shi SY, Zhang G, Zhan SY, Sun F
- Issue date: 2020 Dec 10
- Methods to systematically review and meta-analyse observational studies: a systematic scoping review of recommendations.
- Authors: Mueller M, D'Addario M, Egger M, Cevallos M, Dekkers O, Mugglin C, Scott P
- Issue date: 2018 May 21
- Bias due to selective inclusion and reporting of outcomes and analyses in systematic reviews of randomised trials of healthcare interventions.
- Authors: Page MJ, McKenzie JE, Kirkham J, Dwan K, Kramer S, Green S, Forbes A
- Issue date: 2014 Oct 1
- Healthcare outcomes assessed with observational study designs compared with those assessed in randomized trials.
- Authors: Anglemyer A, Horvath HT, Bero L
- Issue date: 2014 Apr 29
- Evidence-based medicine, systematic reviews, and guidelines in interventional pain management: part 6. Systematic reviews and meta-analyses of observational studies.
- Authors: Manchikanti L, Datta S, Smith HS, Hirsch JA
- Issue date: 2009 Sep-Oct